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000151522 0247_ $$2doi$$a10.1093/geronb/gby083
000151522 0247_ $$2ISSN$$a1079-5014
000151522 0247_ $$2ISSN$$a1758-5368
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000151522 0247_ $$2pmid$$apmid:29986090
000151522 037__ $$aDZNE-2020-01106
000151522 041__ $$aEnglish
000151522 082__ $$a570
000151522 1001_ $$0P:(DE-HGF)0$$aHeser, Kathrin$$b0$$eCorresponding author
000151522 245__ $$aLate-Life Depressive Symptoms Are Associated With Functional Impairment Cross-sectionally and Over Time: Results of the AgeMooDe Study
000151522 260__ $$aOxford [u.a.]$$bOxford Univ. Press$$c2018
000151522 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2018-07-06
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000151522 520__ $$aObjectivesThis study examines the relationship between late-life depressive symptoms, cognitive and functional impairment in a cohort of very old community-based participants.MethodsA sample of 1,226 primary care patients was assessed at baseline (Mage = 80.6 years). Statistical analyses were conducted using baseline and 12-month follow-up data.ResultsAt baseline, depressed participants showed minor cognitive deficits compared with nondepressed participants, whereas functional deficits were pronounced. Depressive symptoms and global cognition were not associated longitudinally. In contrast, follow-up functional impairment was predicted by baseline level and increase of depressive symptoms between baseline and follow-up. Reversely, follow-up depressive symptoms were predicted by functional decline between baseline and follow-up, whereas baseline functional status was not predictive.DiscussionDepressive symptoms and global cognitive function were not associated longitudinally, but level and increase of depressive symptoms over time predicted functional impairment after 1 year. Interventions to reduce depressive symptoms, or to encourage coping strategies might be promising to reduce functional impairment. Elevated follow-up depressive symptoms were only predicted by functional decline, supposedly emphasizing that incident functional impairment might be associated with an acute increase of depressive symptoms. Psychological adjustment processes were not examined, but might be targeted in future.
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000151522 650_2 $$2MeSH$$aActivities of Daily Living: psychology
000151522 650_2 $$2MeSH$$aAge Factors
000151522 650_2 $$2MeSH$$aAged
000151522 650_2 $$2MeSH$$aAged, 80 and over
000151522 650_2 $$2MeSH$$aAging: psychology
000151522 650_2 $$2MeSH$$aCognitive Dysfunction: complications
000151522 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000151522 650_2 $$2MeSH$$aCohort Studies
000151522 650_2 $$2MeSH$$aDepression: complications
000151522 650_2 $$2MeSH$$aDepression: psychology
000151522 650_2 $$2MeSH$$aFemale
000151522 650_2 $$2MeSH$$aFollow-Up Studies
000151522 650_2 $$2MeSH$$aGeriatric Assessment
000151522 650_2 $$2MeSH$$aHumans
000151522 650_2 $$2MeSH$$aLongitudinal Studies
000151522 650_2 $$2MeSH$$aMale
000151522 650_2 $$2MeSH$$aRisk Factors
000151522 7001_ $$aStein, Janine$$b1
000151522 7001_ $$aLuppa, Melanie$$b2
000151522 7001_ $$aWiese, Birgitt$$b3
000151522 7001_ $$aMamone, Silke$$b4
000151522 7001_ $$aWeyerer, Siegfried$$b5
000151522 7001_ $$aWerle, Jochen$$b6
000151522 7001_ $$aKönig, Hans-Helmut$$b7
000151522 7001_ $$aHajek, André$$b8
000151522 7001_ $$aScherer, Martin$$b9
000151522 7001_ $$aStark, Anne$$b10
000151522 7001_ $$aKaduszkiewicz, Hanna$$b11
000151522 7001_ $$0P:(DE-HGF)0$$aMaier, Wolfgang$$b12
000151522 7001_ $$aRiedel-Heller, Steffi G$$b13
000151522 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b14$$eLast author
000151522 77318 $$2Crossref$$3journal-article$$a10.1093/geronb/gby083$$b : Oxford University Press (OUP), 2018-07-06$$tThe Journals of Gerontology: Series B$$x1079-5014$$y2018
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