Journal Article

DZNE-2020-01106

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Late-Life Depressive Symptoms Are Associated With Functional Impairment Cross-sectionally and Over Time: Results of the AgeMooDe Study

Heser, K. (Corresponding author) ; Stein, J. ; Luppa, M. ; Wiese, B. ; Mamone, S. ; Weyerer, S. ; Werle, J. ; König, H.-H. ; Hajek, A. ; Scherer, M. ; Stark, A. ; Kaduszkiewicz, H. ; Maier, W. ; Riedel-Heller, S. G. ; Wagner, M. (Last author)DZNE*

2018
Oxford Univ. Press Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1093/geronb/gby083

Abstract: ObjectivesThis study examines the relationship between late-life depressive symptoms, cognitive and functional impairment in a cohort of very old community-based participants.MethodsA sample of 1,226 primary care patients was assessed at baseline (Mage = 80.6 years). Statistical analyses were conducted using baseline and 12-month follow-up data.ResultsAt baseline, depressed participants showed minor cognitive deficits compared with nondepressed participants, whereas functional deficits were pronounced. Depressive symptoms and global cognition were not associated longitudinally. In contrast, follow-up functional impairment was predicted by baseline level and increase of depressive symptoms between baseline and follow-up. Reversely, follow-up depressive symptoms were predicted by functional decline between baseline and follow-up, whereas baseline functional status was not predictive.DiscussionDepressive symptoms and global cognitive function were not associated longitudinally, but level and increase of depressive symptoms over time predicted functional impairment after 1 year. Interventions to reduce depressive symptoms, or to encourage coping strategies might be promising to reduce functional impairment. Elevated follow-up depressive symptoms were only predicted by functional decline, supposedly emphasizing that incident functional impairment might be associated with an acute increase of depressive symptoms. Psychological adjustment processes were not examined, but might be targeted in future.

Keyword(s): Activities of Daily Living: psychology (MeSH) ; Age Factors (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Aging: psychology (MeSH) ; Cognitive Dysfunction: complications (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Cohort Studies (MeSH) ; Depression: complications (MeSH) ; Depression: psychology (MeSH) ; Female (MeSH) ; Follow-Up Studies (MeSH) ; Geriatric Assessment (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Risk Factors (MeSH)

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Contributing Institute(s):

1. Bonn Pre 2020 (Bonn Pre 2020)

Research Program(s):

1. 899H - Addenda (POF3-899H) (POF3-899H)

Appears in the scientific report 2018

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Social Sciences Citation Index ; Web of Science Core Collection

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