TY  - JOUR
AU  - Heser, Kathrin
AU  - Stein, Janine
AU  - Luppa, Melanie
AU  - Wiese, Birgitt
AU  - Mamone, Silke
AU  - Weyerer, Siegfried
AU  - Werle, Jochen
AU  - König, Hans-Helmut
AU  - Hajek, André
AU  - Scherer, Martin
AU  - Stark, Anne
AU  - Kaduszkiewicz, Hanna
AU  - Maier, Wolfgang
AU  - Riedel-Heller, Steffi G
AU  - Wagner, Michael
TI  - Late-Life Depressive Symptoms Are Associated With Functional Impairment Cross-sectionally and Over Time: Results of the AgeMooDe Study
JO  - The journals of gerontology / B
VL  - 75
IS  - 4
SN  - 1079-5014
CY  - Oxford [u.a.]
PB  - Oxford Univ. Press
M1  - DZNE-2020-01106
SP  - 811 - 820
PY  - 2018
AB  - ObjectivesThis study examines the relationship between late-life depressive symptoms, cognitive and functional impairment in a cohort of very old community-based participants.MethodsA sample of 1,226 primary care patients was assessed at baseline (Mage = 80.6 years). Statistical analyses were conducted using baseline and 12-month follow-up data.ResultsAt baseline, depressed participants showed minor cognitive deficits compared with nondepressed participants, whereas functional deficits were pronounced. Depressive symptoms and global cognition were not associated longitudinally. In contrast, follow-up functional impairment was predicted by baseline level and increase of depressive symptoms between baseline and follow-up. Reversely, follow-up depressive symptoms were predicted by functional decline between baseline and follow-up, whereas baseline functional status was not predictive.DiscussionDepressive symptoms and global cognitive function were not associated longitudinally, but level and increase of depressive symptoms over time predicted functional impairment after 1 year. Interventions to reduce depressive symptoms, or to encourage coping strategies might be promising to reduce functional impairment. Elevated follow-up depressive symptoms were only predicted by functional decline, supposedly emphasizing that incident functional impairment might be associated with an acute increase of depressive symptoms. Psychological adjustment processes were not examined, but might be targeted in future.
KW  - Activities of Daily Living: psychology
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Aging: psychology
KW  - Cognitive Dysfunction: complications
KW  - Cognitive Dysfunction: psychology
KW  - Cohort Studies
KW  - Depression: complications
KW  - Depression: psychology
KW  - Female
KW  - Follow-Up Studies
KW  - Geriatric Assessment
KW  - Humans
KW  - Longitudinal Studies
KW  - Male
KW  - Risk Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:29986090
DO  - DOI:10.1093/geronb/gby083
UR  - https://pub.dzne.de/record/151522
ER  -