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@ARTICLE{Heser:151522,
      author       = {Heser, Kathrin and Stein, Janine and Luppa, Melanie and
                      Wiese, Birgitt and Mamone, Silke and Weyerer, Siegfried and
                      Werle, Jochen and König, Hans-Helmut and Hajek, André and
                      Scherer, Martin and Stark, Anne and Kaduszkiewicz, Hanna and
                      Maier, Wolfgang and Riedel-Heller, Steffi G and Wagner,
                      Michael},
      title        = {{L}ate-{L}ife {D}epressive {S}ymptoms {A}re {A}ssociated
                      {W}ith {F}unctional {I}mpairment {C}ross-sectionally and
                      {O}ver {T}ime: {R}esults of the {A}ge{M}oo{D}e {S}tudy},
      journal      = {The journals of gerontology / B},
      volume       = {75},
      number       = {4},
      issn         = {1079-5014},
      address      = {Oxford [u.a.]},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2020-01106},
      pages        = {811 - 820},
      year         = {2018},
      abstract     = {ObjectivesThis study examines the relationship between
                      late-life depressive symptoms, cognitive and functional
                      impairment in a cohort of very old community-based
                      participants.MethodsA sample of 1,226 primary care patients
                      was assessed at baseline (Mage = 80.6 years). Statistical
                      analyses were conducted using baseline and 12-month
                      follow-up data.ResultsAt baseline, depressed participants
                      showed minor cognitive deficits compared with nondepressed
                      participants, whereas functional deficits were pronounced.
                      Depressive symptoms and global cognition were not associated
                      longitudinally. In contrast, follow-up functional impairment
                      was predicted by baseline level and increase of depressive
                      symptoms between baseline and follow-up. Reversely,
                      follow-up depressive symptoms were predicted by functional
                      decline between baseline and follow-up, whereas baseline
                      functional status was not predictive.DiscussionDepressive
                      symptoms and global cognitive function were not associated
                      longitudinally, but level and increase of depressive
                      symptoms over time predicted functional impairment after 1
                      year. Interventions to reduce depressive symptoms, or to
                      encourage coping strategies might be promising to reduce
                      functional impairment. Elevated follow-up depressive
                      symptoms were only predicted by functional decline,
                      supposedly emphasizing that incident functional impairment
                      might be associated with an acute increase of depressive
                      symptoms. Psychological adjustment processes were not
                      examined, but might be targeted in future.},
      keywords     = {Activities of Daily Living: psychology / Age Factors / Aged
                      / Aged, 80 and over / Aging: psychology / Cognitive
                      Dysfunction: complications / Cognitive Dysfunction:
                      psychology / Cohort Studies / Depression: complications /
                      Depression: psychology / Female / Follow-Up Studies /
                      Geriatric Assessment / Humans / Longitudinal Studies / Male
                      / Risk Factors},
      cin          = {Bonn Pre 2020},
      ddc          = {570},
      cid          = {I:(DE-2719)6000011},
      pnm          = {899H - Addenda (POF3-899H)},
      pid          = {G:(DE-HGF)POF3-899H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29986090},
      doi          = {10.1093/geronb/gby083},
      url          = {https://pub.dzne.de/record/151522},
}