%0 Journal Article
%A Heser, Kathrin
%A Kleineidam, Luca
%A Pabst, Alexander
%A Wiese, Birgitt
%A Roehr, Susanne
%A Löbner, Margrit
%A Hajek, André
%A van der Leeden, Carolin
%A Angermeyer, Matthias C.
%A Scherer, Martin
%A König, Hans-Helmut
%A Maier, Wolfgang
%A Riedel-Heller, Steffi G.
%A Wagner, Michael
%T Sex-Specific Associations Between Depressive Symptoms and Risk for Subsequent Dementia
%J Journal of Alzheimer's disease
%V 74
%N 1
%@ 1387-2877
%C Amsterdam
%I IOS Press
%M DZNE-2020-01158
%P 151-161
%D 2020
%X Background:An association between depression and an increased risk for subsequent dementia is well-established. Sexspecific associations are understudied yet.Objective:We aimed to investigate sex-specific associations between depressive symptoms and dementia risk.Methods:Longitudinal analyses were conducted in a pooled data set (n = 4,255, mean age = 80 years) of two prospective cohort studies (LEILA 75+, AgeCoDe). Depressive symptoms were harmonized by dichotomized scores of two different depression screening scales using established cutoffs. Transition to dementia was used as outcome in Cox proportional hazards models.Results:Depressive symptoms at baseline were associated with an increased risk for subsequent dementia, and this association was more pronounced in males (interaction of depressive symptoms × sex: HR = 1.64, 95
%K Aged
%K Aged, 80 and over
%K Cohort Studies
%K Dementia: complications
%K Dementia: epidemiology
%K Dementia: psychology
%K Depression: complications
%K Depression: epidemiology
%K Depression: psychology
%K Disease Progression
%K Educational Status
%K Female
%K Geriatric Assessment
%K Germany: epidemiology
%K Humans
%K Longitudinal Studies
%K Male
%K Mass Screening
%K Middle Aged
%K Neuropsychological Tests
%K Prospective Studies
%K Psychiatric Status Rating Scales
%K Risk
%K Sex Factors
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31985459
%R 10.3233/JAD-190770
%U https://pub.dzne.de/record/151574