Journal Article

DZNE-2020-01158

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex-Specific Associations Between Depressive Symptoms and Risk for Subsequent Dementia

Heser, K. (Corresponding author) ; Kleineidam, L. ; Pabst, A. ; Wiese, B. ; Roehr, S. ; Löbner, M. ; Hajek, A. ; van der Leeden, C. ; Angermeyer, M. C. ; Scherer, M. ; König, H.-H. ; Maier, W. ; Riedel-Heller, S. G. ; Wagner, M. (Last author)DZNE*

2020
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JAD-190770

Abstract: Background:An association between depression and an increased risk for subsequent dementia is well-established. Sexspecific associations are understudied yet.Objective:We aimed to investigate sex-specific associations between depressive symptoms and dementia risk.Methods:Longitudinal analyses were conducted in a pooled data set (n = 4,255, mean age = 80 years) of two prospective cohort studies (LEILA 75+, AgeCoDe). Depressive symptoms were harmonized by dichotomized scores of two different depression screening scales using established cutoffs. Transition to dementia was used as outcome in Cox proportional hazards models.Results:Depressive symptoms at baseline were associated with an increased risk for subsequent dementia, and this association was more pronounced in males (interaction of depressive symptoms × sex: HR = 1.64, 95% CI: 1.02–2.64, p = 0.042) in a model adjusted for study, age, and education. After additional adjustment for subjective and objective cognition, depressive symptoms and their interaction with sex (HR = 1.38, 95% CI: 0.85–2.23, p = 0.188) were no longer significantly associated with the risk for subsequent dementia. Sex-stratified analyses showed stronger and significant associations between depressive symptoms and subsequent dementia in men (e.g., HR= 2.10, 95% CI: 1.36–3.23, p = 0.001, compared to HR= 1.28, 95% CI: 1.04–1.58, p = 0.020, in women).Conclusions:Overall, we provide evidence for a stronger association between depression and dementia in men compared to women. Depressive symptoms should be diagnosed, monitored, and treated, not only due to depression, but also with respect to the risk for subsequent dementia, especially in elderly men.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Cohort Studies (MeSH) ; Dementia: complications (MeSH) ; Dementia: epidemiology (MeSH) ; Dementia: psychology (MeSH) ; Depression: complications (MeSH) ; Depression: epidemiology (MeSH) ; Depression: psychology (MeSH) ; Disease Progression (MeSH) ; Educational Status (MeSH) ; Female (MeSH) ; Geriatric Assessment (MeSH) ; Germany: epidemiology (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Male (MeSH) ; Mass Screening (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Prospective Studies (MeSH) ; Psychiatric Status Rating Scales (MeSH) ; Risk (MeSH) ; Sex Factors (MeSH)

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Contributing Institute(s):

1. Bonn common (Bonn common)
2. Neuropsychology (AG Wagner)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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