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000151574 0247_ $$2doi$$a10.3233/JAD-190770
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000151574 0247_ $$2ISSN$$a1875-8908
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000151574 041__ $$aEnglish
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000151574 1001_ $$0P:(DE-HGF)0$$aHeser, Kathrin$$b0$$eCorresponding author
000151574 245__ $$aSex-Specific Associations Between Depressive Symptoms and Risk for Subsequent Dementia
000151574 260__ $$aAmsterdam$$bIOS Press$$c2020
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000151574 520__ $$aBackground:An association between depression and an increased risk for subsequent dementia is well-established. Sexspecific associations are understudied yet.Objective:We aimed to investigate sex-specific associations between depressive symptoms and dementia risk.Methods:Longitudinal analyses were conducted in a pooled data set (n = 4,255, mean age = 80 years) of two prospective cohort studies (LEILA 75+, AgeCoDe). Depressive symptoms were harmonized by dichotomized scores of two different depression screening scales using established cutoffs. Transition to dementia was used as outcome in Cox proportional hazards models.Results:Depressive symptoms at baseline were associated with an increased risk for subsequent dementia, and this association was more pronounced in males (interaction of depressive symptoms × sex: HR = 1.64, 95% CI: 1.02–2.64, p = 0.042) in a model adjusted for study, age, and education. After additional adjustment for subjective and objective cognition, depressive symptoms and their interaction with sex (HR = 1.38, 95% CI: 0.85–2.23, p = 0.188) were no longer significantly associated with the risk for subsequent dementia. Sex-stratified analyses showed stronger and significant associations between depressive symptoms and subsequent dementia in men (e.g., HR= 2.10, 95% CI: 1.36–3.23, p = 0.001, compared to HR= 1.28, 95% CI: 1.04–1.58, p = 0.020, in women).Conclusions:Overall, we provide evidence for a stronger association between depression and dementia in men compared to women. Depressive symptoms should be diagnosed, monitored, and treated, not only due to depression, but also with respect to the risk for subsequent dementia, especially in elderly men.
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000151574 650_2 $$2MeSH$$aAged
000151574 650_2 $$2MeSH$$aAged, 80 and over
000151574 650_2 $$2MeSH$$aCohort Studies
000151574 650_2 $$2MeSH$$aDementia: complications
000151574 650_2 $$2MeSH$$aDementia: epidemiology
000151574 650_2 $$2MeSH$$aDementia: psychology
000151574 650_2 $$2MeSH$$aDepression: complications
000151574 650_2 $$2MeSH$$aDepression: epidemiology
000151574 650_2 $$2MeSH$$aDepression: psychology
000151574 650_2 $$2MeSH$$aDisease Progression
000151574 650_2 $$2MeSH$$aEducational Status
000151574 650_2 $$2MeSH$$aFemale
000151574 650_2 $$2MeSH$$aGeriatric Assessment
000151574 650_2 $$2MeSH$$aGermany: epidemiology
000151574 650_2 $$2MeSH$$aHumans
000151574 650_2 $$2MeSH$$aLongitudinal Studies
000151574 650_2 $$2MeSH$$aMale
000151574 650_2 $$2MeSH$$aMass Screening
000151574 650_2 $$2MeSH$$aMiddle Aged
000151574 650_2 $$2MeSH$$aNeuropsychological Tests
000151574 650_2 $$2MeSH$$aProspective Studies
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000151574 7001_ $$0P:(DE-HGF)0$$aKleineidam, Luca$$b1
000151574 7001_ $$aPabst, Alexander$$b2
000151574 7001_ $$aWiese, Birgitt$$b3
000151574 7001_ $$aRoehr, Susanne$$b4
000151574 7001_ $$aLöbner, Margrit$$b5
000151574 7001_ $$aHajek, André$$b6
000151574 7001_ $$avan der Leeden, Carolin$$b7
000151574 7001_ $$aAngermeyer, Matthias C.$$b8
000151574 7001_ $$aScherer, Martin$$b9
000151574 7001_ $$aKönig, Hans-Helmut$$b10
000151574 7001_ $$0P:(DE-HGF)0$$aMaier, Wolfgang$$b11
000151574 7001_ $$aRiedel-Heller, Steffi G.$$b12
000151574 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b13$$eLast author$$udzne
000151574 77318 $$2Crossref$$3journal-article$$a10.3233/jad-190770$$b : IOS Press, 2020-03-10$$n1$$p151-161$$tJournal of Alzheimer's Disease$$v74$$x1387-2877$$y2020
000151574 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-190770$$gVol. 74, no. 1, p. 151 - 161$$n1$$p151-161$$tJournal of Alzheimer's disease$$v74$$x1387-2877$$y2020
000151574 8564_ $$uhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad190770
000151574 8564_ $$uhttps://pub.dzne.de/record/151574/files/DZNE-2020-01158_Restricted.pdf
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