TY  - JOUR
AU  - Heser, Kathrin
AU  - Kleineidam, Luca
AU  - Pabst, Alexander
AU  - Wiese, Birgitt
AU  - Roehr, Susanne
AU  - Löbner, Margrit
AU  - Hajek, André
AU  - van der Leeden, Carolin
AU  - Angermeyer, Matthias C.
AU  - Scherer, Martin
AU  - König, Hans-Helmut
AU  - Maier, Wolfgang
AU  - Riedel-Heller, Steffi G.
AU  - Wagner, Michael
TI  - Sex-Specific Associations Between Depressive Symptoms and Risk for Subsequent Dementia
JO  - Journal of Alzheimer's disease
VL  - 74
IS  - 1
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-01158
SP  - 151-161
PY  - 2020
AB  - Background:An association between depression and an increased risk for subsequent dementia is well-established. Sexspecific associations are understudied yet.Objective:We aimed to investigate sex-specific associations between depressive symptoms and dementia risk.Methods:Longitudinal analyses were conducted in a pooled data set (n = 4,255, mean age = 80 years) of two prospective cohort studies (LEILA 75+, AgeCoDe). Depressive symptoms were harmonized by dichotomized scores of two different depression screening scales using established cutoffs. Transition to dementia was used as outcome in Cox proportional hazards models.Results:Depressive symptoms at baseline were associated with an increased risk for subsequent dementia, and this association was more pronounced in males (interaction of depressive symptoms × sex: HR = 1.64, 95
KW  - Aged
KW  - Aged, 80 and over
KW  - Cohort Studies
KW  - Dementia: complications
KW  - Dementia: epidemiology
KW  - Dementia: psychology
KW  - Depression: complications
KW  - Depression: epidemiology
KW  - Depression: psychology
KW  - Disease Progression
KW  - Educational Status
KW  - Female
KW  - Geriatric Assessment
KW  - Germany: epidemiology
KW  - Humans
KW  - Longitudinal Studies
KW  - Male
KW  - Mass Screening
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Prospective Studies
KW  - Psychiatric Status Rating Scales
KW  - Risk
KW  - Sex Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:31985459
DO  - DOI:10.3233/JAD-190770
UR  - https://pub.dzne.de/record/151574
ER  -