% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Heser:151574,
      author       = {Heser, Kathrin and Kleineidam, Luca and Pabst, Alexander
                      and Wiese, Birgitt and Roehr, Susanne and Löbner, Margrit
                      and Hajek, André and van der Leeden, Carolin and
                      Angermeyer, Matthias C. and Scherer, Martin and König,
                      Hans-Helmut and Maier, Wolfgang and Riedel-Heller, Steffi G.
                      and Wagner, Michael},
      title        = {{S}ex-{S}pecific {A}ssociations {B}etween {D}epressive
                      {S}ymptoms and {R}isk for {S}ubsequent {D}ementia},
      journal      = {Journal of Alzheimer's disease},
      volume       = {74},
      number       = {1},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2020-01158},
      pages        = {151-161},
      year         = {2020},
      abstract     = {Background:An association between depression and an
                      increased risk for subsequent dementia is well-established.
                      Sexspecific associations are understudied yet.Objective:We
                      aimed to investigate sex-specific associations between
                      depressive symptoms and dementia risk.Methods:Longitudinal
                      analyses were conducted in a pooled data set (n = 4,255,
                      mean age = 80 years) of two prospective cohort studies
                      (LEILA 75+, AgeCoDe). Depressive symptoms were harmonized by
                      dichotomized scores of two different depression screening
                      scales using established cutoffs. Transition to dementia was
                      used as outcome in Cox proportional hazards
                      models.Results:Depressive symptoms at baseline were
                      associated with an increased risk for subsequent dementia,
                      and this association was more pronounced in males
                      (interaction of depressive symptoms × sex: HR = 1.64,
                      $95\%$ CI: 1.02–2.64, p = 0.042) in a model adjusted for
                      study, age, and education. After additional adjustment for
                      subjective and objective cognition, depressive symptoms and
                      their interaction with sex (HR = 1.38, $95\%$ CI:
                      0.85–2.23, p = 0.188) were no longer significantly
                      associated with the risk for subsequent dementia.
                      Sex-stratified analyses showed stronger and significant
                      associations between depressive symptoms and subsequent
                      dementia in men (e.g., HR= 2.10, $95\%$ CI: 1.36–3.23, p =
                      0.001, compared to HR= 1.28, $95\%$ CI: 1.04–1.58, p =
                      0.020, in women).Conclusions:Overall, we provide evidence
                      for a stronger association between depression and dementia
                      in men compared to women. Depressive symptoms should be
                      diagnosed, monitored, and treated, not only due to
                      depression, but also with respect to the risk for subsequent
                      dementia, especially in elderly men.},
      keywords     = {Aged / Aged, 80 and over / Cohort Studies / Dementia:
                      complications / Dementia: epidemiology / Dementia:
                      psychology / Depression: complications / Depression:
                      epidemiology / Depression: psychology / Disease Progression
                      / Educational Status / Female / Geriatric Assessment /
                      Germany: epidemiology / Humans / Longitudinal Studies / Male
                      / Mass Screening / Middle Aged / Neuropsychological Tests /
                      Prospective Studies / Psychiatric Status Rating Scales /
                      Risk / Sex Factors},
      cin          = {Bonn common / AG Wagner},
      ddc          = {610},
      cid          = {I:(DE-2719)6000011 / I:(DE-2719)1011201},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31985459},
      doi          = {10.3233/JAD-190770},
      url          = {https://pub.dzne.de/record/151574},
}