Journal Article

DZNE-2020-01306

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Acceptability and Validity of the EQ-5D in Patients Living With Dementia.

Michalowsky, B.DZNE* ; Xie, F. (Corresponding author) ; Kohlmann, T. ; Gräske, J. ; Wübbeler, M. ; Thyrian, J. R.DZNE* ; Hoffmann, W. (Last author)DZNE*

2020
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jval.2020.01.022

Abstract: To assess the acceptability and validity of the 3 levels of the EQ-5D (EQ-5D-3L) compared with the Quality of Life in Alzheimer's Diseases (QoL-AD) in patients living with dementia.The analysis was based on 560 dyads of persons with dementia and their caregivers of the multicenter observational study of dementia care networks in Germany (DemNet-D). Health-related quality of life was assessed by face-to-face interviews using the EQ-5D-3L (self-rating) and the QoL-AD (self- and proxy-rating). The number of missing values, the score ranges (observed vs possible range) and the floor and ceiling effects were used to assess the acceptability. We used one-way analyses of variance and multivariate linear regression models to evaluate the discriminative ability. The convergent validity was assessed using Spearman's correlation coefficient (rs) and multivariate regression models.The EQ-5D index had a higher response rate (89% vs 84%) and a comparable floor (>1%) but a higher ceiling effect (18% vs >1%) compared with the QoL-AD. Both measures can significantly differentiate between different stages of general health, instrumental activities of daily living, and depression. The EQ-5D index and the visual analog scale self-rating scores strongly correlated with the QoL-AD self-rating (rs = 0.644 and 0.553, respectively) but not with the proxy-rating score (rs = 0.314 and rs = 0.170, respectively), which was confirmed by multivariate regression analyses.The results satisfy acceptability, discriminative ability, and convergent validity for moderately cognitively and functionally impaired patients living with dementia. The EQ-5D-3L performed comparably with the QoL-AD, and could, therefore, be used in economic evaluations in dementia. The differences between self- and proxy-ratings should be evaluated and considered in the interpretation of health-related quality of life scores.

Keyword(s): Activities of Daily Living (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: psychology (MeSH) ; Caregivers: psychology (MeSH) ; Dementia: psychology (MeSH) ; Depression: epidemiology (MeSH) ; Female (MeSH) ; Germany (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Patient Reported Outcome Measures (MeSH) ; Quality of Life (MeSH) ; Reproducibility of Results (MeSH) ; Surveys and Questionnaires (MeSH)

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Contributing Institute(s):

1. Interventional Health Care Research (IHCR) (AG Thyrian)
2. Translational Health Care Research (AG Hoffmann)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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