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000153423 1001_ $$0P:(DE-2719)2810548$$aZocher, Sara$$b0$$eFirst author
000153423 245__ $$aEarly-life environmental enrichment generates persistent individualized behavior in mice
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000153423 520__ $$aIndividuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics.
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000153423 7001_ $$00000-0003-3399-4067$$aSchilling, Susan$$b1
000153423 7001_ $$0P:(DE-2719)2810902$$aGrzyb, Anna$$b2
000153423 7001_ $$0P:(DE-2719)2810887$$aAdusumilli, Vijay S.$$b3
000153423 7001_ $$0P:(DE-2719)9001448$$aBogado Lopes, Jadna$$b4
000153423 7001_ $$0P:(DE-2719)2810596$$aGünther, Sandra$$b5
000153423 7001_ $$0P:(DE-2719)2812530$$aOverall, Rupert$$b6
000153423 7001_ $$00000-0002-7828-1872$$aWinter, York$$b7
000153423 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b8$$eLast author
000153423 773__ $$0PERI:(DE-600)2810933-8$$a10.1126/sciadv.abb1478$$gVol. 6, no. 35, p. eabb1478 -$$n35$$peabb1478$$tScience advances$$v6$$x2375-2548$$y2020
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000153423 9201_ $$0I:(DE-2719)1740001$$kAG Garthe$$lNeurobiology of Behaviour$$x0
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