Journal Article

DZNE-2020-01420

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Early-life environmental enrichment generates persistent individualized behavior in mice

Zocher, S. (First author)DZNE* ; Schilling, S. ; Grzyb, A.DZNE* ; Adusumilli, V. S.DZNE* ; Bogado Lopes, J.DZNE* ; Günther, S.DZNE* ; Overall, R.DZNE* ; Winter, Y. ; Kempermann, G. (Last author)DZNE*

2020
Assoc. Washington, DC [u.a.]

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Please use a persistent id in citations: doi:10.1126/sciadv.abb1478

Abstract: Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics.

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Contributing Institute(s):

1. Neurobiology of Behaviour (AG Garthe)
2. Adult Neurogenesis (AG Kempermann)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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