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@ARTICLE{Zocher:153423,
      author       = {Zocher, Sara and Schilling, Susan and Grzyb, Anna and
                      Adusumilli, Vijay S. and Bogado Lopes, Jadna and Günther,
                      Sandra and Overall, Rupert and Winter, York and Kempermann,
                      Gerd},
      title        = {{E}arly-life environmental enrichment generates persistent
                      individualized behavior in mice},
      journal      = {Science advances},
      volume       = {6},
      number       = {35},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DZNE-2020-01420},
      pages        = {eabb1478},
      year         = {2020},
      abstract     = {Individuals differ in their response to environmental
                      stimuli, but the stability of individualized behaviors and
                      their associated changes in brain plasticity are poorly
                      understood. We developed a novel model of enriched
                      environment to longitudinally monitor 40 inbred mice
                      exploring 35 connected cages over periods of 3 to 6 months.
                      We show that behavioral individuality that emerged during
                      the first 3 months of environmental enrichment persisted
                      when mice were withdrawn from the enriched environment for 3
                      additional months. Behavioral trajectories were associated
                      with stable interindividual differences in adult hippocampal
                      neurogenesis and persistent epigenetic effects on neuronal
                      plasticity genes in the hippocampus. Using genome-wide DNA
                      methylation sequencing, we show that one-third of the DNA
                      methylation changes were maintained after withdrawal from
                      the enriched environment. Our results suggest that, even
                      under conditions that control genetic background and shared
                      environment, early-life experiences result in lasting
                      individualized changes in behavior, brain plasticity, and
                      epigenetics.},
      cin          = {AG Garthe / AG Kempermann},
      ddc          = {500},
      cid          = {I:(DE-2719)1740001 / I:(DE-2719)1710001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7449688},
      pubmed       = {pmid:32923634},
      doi          = {10.1126/sciadv.abb1478},
      url          = {https://pub.dzne.de/record/153423},
}