Home > Publications Database > Early-life environmental enrichment generates persistent individualized behavior in mice > print

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024 7 _ |a 10.1126/sciadv.abb1478
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041 _ _ |a English
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100 1 _ |a Zocher, Sara
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245 _ _ |a Early-life environmental enrichment generates persistent individualized behavior in mice
260 _ _ |a Washington, DC [u.a.]
|c 2020
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520 _ _ |a Individuals differ in their response to environmental stimuli, but the stability of individualized behaviors and their associated changes in brain plasticity are poorly understood. We developed a novel model of enriched environment to longitudinally monitor 40 inbred mice exploring 35 connected cages over periods of 3 to 6 months. We show that behavioral individuality that emerged during the first 3 months of environmental enrichment persisted when mice were withdrawn from the enriched environment for 3 additional months. Behavioral trajectories were associated with stable interindividual differences in adult hippocampal neurogenesis and persistent epigenetic effects on neuronal plasticity genes in the hippocampus. Using genome-wide DNA methylation sequencing, we show that one-third of the DNA methylation changes were maintained after withdrawal from the enriched environment. Our results suggest that, even under conditions that control genetic background and shared environment, early-life experiences result in lasting individualized changes in behavior, brain plasticity, and epigenetics.
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700 1 _ |a Schilling, Susan
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700 1 _ |a Grzyb, Anna
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700 1 _ |a Adusumilli, Vijay S.
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700 1 _ |a Bogado Lopes, Jadna
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700 1 _ |a Günther, Sandra
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700 1 _ |a Overall, Rupert
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700 1 _ |a Winter, York
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700 1 _ |a Kempermann, Gerd
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773 _ _ |a 10.1126/sciadv.abb1478
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856 4 _ |u https://advances.sciencemag.org/content/6/35/eabb1478/tab-pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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