%0 Journal Article
%A Nyberg, Lars
%A Grande, Xenia
%A Andersson, Micael
%A Berron, David
%A Lundquist, Anders
%A Stiernstedt, Mikael
%A Fjell, Anders
%A Walhovd, Kristine
%A Orädd, Greger
%T Forecasting memory function in aging: pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years
%J Neurobiology of aging
%V 94
%@ 0197-4580
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2020-01429
%P 217 - 226
%D 2020
%X Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.
%K Age Factors
%K Aged
%K Aged, 80 and over
%K Aging: physiology
%K Aging: psychology
%K Cognition: physiology
%K Diffusion Magnetic Resonance Imaging
%K Female
%K Forecasting
%K Hippocampus: diagnostic imaging
%K Hippocampus: physiology
%K Humans
%K Magnetic Resonance Imaging
%K Male
%K Memory: physiology
%K Middle Aged
%K Pattern Recognition, Visual: physiology
%K Spatial Processing: physiology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32650185
%R 10.1016/j.neurobiolaging.2020.06.005
%U https://pub.dzne.de/record/153432