Journal Article

DZNE-2020-01429

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Forecasting memory function in aging: pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years

Nyberg, L. (Corresponding author) ; Grande, X.DZNE* ; Andersson, M. ; Berron, D.DZNE* ; Lundquist, A. ; Stiernstedt, M. ; Fjell, A. ; Walhovd, K. ; Orädd, G.

2020
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neurobiolaging.2020.06.005

Abstract: Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.

Keyword(s): Age Factors (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Aging: physiology (MeSH) ; Aging: psychology (MeSH) ; Cognition: physiology (MeSH) ; Diffusion Magnetic Resonance Imaging (MeSH) ; Female (MeSH) ; Forecasting (MeSH) ; Hippocampus: diagnostic imaging (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Memory: physiology (MeSH) ; Middle Aged (MeSH) ; Pattern Recognition, Visual: physiology (MeSH) ; Spatial Processing: physiology (MeSH)

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Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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