TY  - JOUR
AU  - Nyberg, Lars
AU  - Grande, Xenia
AU  - Andersson, Micael
AU  - Berron, David
AU  - Lundquist, Anders
AU  - Stiernstedt, Mikael
AU  - Fjell, Anders
AU  - Walhovd, Kristine
AU  - Orädd, Greger
TI  - Forecasting memory function in aging: pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years
JO  - Neurobiology of aging
VL  - 94
SN  - 0197-4580
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-01429
SP  - 217 - 226
PY  - 2020
AB  - Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Aging: physiology
KW  - Aging: psychology
KW  - Cognition: physiology
KW  - Diffusion Magnetic Resonance Imaging
KW  - Female
KW  - Forecasting
KW  - Hippocampus: diagnostic imaging
KW  - Hippocampus: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Memory: physiology
KW  - Middle Aged
KW  - Pattern Recognition, Visual: physiology
KW  - Spatial Processing: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:32650185
DO  - DOI:10.1016/j.neurobiolaging.2020.06.005
UR  - https://pub.dzne.de/record/153432
ER  -