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@ARTICLE{Nyberg:153432,
      author       = {Nyberg, Lars and Grande, Xenia and Andersson, Micael and
                      Berron, David and Lundquist, Anders and Stiernstedt, Mikael
                      and Fjell, Anders and Walhovd, Kristine and Orädd, Greger},
      title        = {{F}orecasting memory function in aging: pattern-completion
                      ability and hippocampal activity relate to visuospatial
                      functioning over 25 years},
      journal      = {Neurobiology of aging},
      volume       = {94},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-01429},
      pages        = {217 - 226},
      year         = {2020},
      abstract     = {Heterogeneity in episodic memory functioning in aging was
                      assessed with a pattern-completion functional magnetic
                      resonance imaging task that required reactivation of
                      well-consolidated face-name memory traces from fragmented
                      (partial) or morphed (noisy) face cues. About half of the
                      examined individuals (N = 101) showed impaired (chance)
                      performance on fragmented faces despite intact performance
                      on complete and morphed faces, and they did not show a
                      pattern-completion response in hippocampus or the examined
                      subfields (CA1, CA23, DGCA4). This apparent
                      pattern-completion deficit could not be explained by
                      differential hippocampal atrophy. Instead, the impaired
                      group displayed lower cortical volumes, accelerated
                      reduction in mini-mental state examination scores, and lower
                      general cognitive function as defined by longitudinal
                      measures of visuospatial functioning and
                      speed-of-processing. In the full sample, inter-individual
                      differences in visuospatial functioning predicted
                      performance on fragmented faces and hippocampal CA23
                      subfield activity over 25 years. These findings suggest that
                      visuospatial functioning in middle age can forecast
                      pattern-completion deficits in aging.},
      keywords     = {Age Factors / Aged / Aged, 80 and over / Aging: physiology
                      / Aging: psychology / Cognition: physiology / Diffusion
                      Magnetic Resonance Imaging / Female / Forecasting /
                      Hippocampus: diagnostic imaging / Hippocampus: physiology /
                      Humans / Magnetic Resonance Imaging / Male / Memory:
                      physiology / Middle Aged / Pattern Recognition, Visual:
                      physiology / Spatial Processing: physiology},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32650185},
      doi          = {10.1016/j.neurobiolaging.2020.06.005},
      url          = {https://pub.dzne.de/record/153432},
}