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000153437 0247_ $$2ISSN$$a1471-003X
000153437 0247_ $$2ISSN$$a1471-0048
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000153437 0247_ $$2pmid$$apmid:32873937
000153437 037__ $$aDZNE-2020-01434
000153437 041__ $$aEnglish
000153437 082__ $$a570
000153437 1001_ $$00000-0002-6800-0942$$aSemyanov, Alexey$$b0
000153437 245__ $$aMaking sense of astrocytic calcium signals — from acquisition to interpretation
000153437 260__ $$aLondon$$bNature Publ. Group$$c2020
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000153437 520__ $$aAstrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed.
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000153437 650_2 $$2MeSH$$aAnimals
000153437 650_2 $$2MeSH$$aAstrocytes: physiology
000153437 650_2 $$2MeSH$$aBrain: physiology
000153437 650_2 $$2MeSH$$aCalcium Signaling: physiology
000153437 650_2 $$2MeSH$$aCells, Cultured
000153437 650_2 $$2MeSH$$aHumans
000153437 650_2 $$2MeSH$$aNeurons: physiology
000153437 650_2 $$2MeSH$$aOptical Imaging
000153437 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b1$$udzne
000153437 7001_ $$00000-0001-7948-4498$$aAgarwal, Amit$$b2
000153437 773__ $$0PERI:(DE-600)2028902-9$$a10.1038/s41583-020-0361-8$$gVol. 21, no. 10, p. 551 - 564$$n10$$p551 - 564$$tNature reviews / Neuroscience$$v21$$x1471-0048$$y2020
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000153437 9141_ $$y2020
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