Journal Article (Review Article)

DZNE-2020-01434

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Making sense of astrocytic calcium signals — from acquisition to interpretation

Semyanov, A. ; Henneberger, C.DZNE* ; Agarwal, A.

2020
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41583-020-0361-8

Abstract: Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed.

Keyword(s): Animals (MeSH) ; Astrocytes: physiology (MeSH) ; Brain: physiology (MeSH) ; Calcium Signaling: physiology (MeSH) ; Cells, Cultured (MeSH) ; Humans (MeSH) ; Neurons: physiology (MeSH) ; Optical Imaging (MeSH)

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Contributing Institute(s):

1. U Clinical Researchers - Bonn (U Clinical Researchers - Bonn)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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