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@ARTICLE{Semyanov:153437,
      author       = {Semyanov, Alexey and Henneberger, Christian and Agarwal,
                      Amit},
      title        = {{M}aking sense of astrocytic calcium signals — from
                      acquisition to interpretation},
      journal      = {Nature reviews / Neuroscience},
      volume       = {21},
      number       = {10},
      issn         = {1471-0048},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2020-01434},
      pages        = {551 - 564},
      year         = {2020},
      abstract     = {Astrocytes functionally interact with neurons and with
                      other brain cells. Although not electrically excitable,
                      astrocytes display a complex repertoire of intracellular
                      Ca2+ signalling that evolves in space and time within single
                      astrocytes and across astrocytic networks. Decoding the
                      physiological meaning of these dynamic changes in astrocytic
                      Ca2+ activity has remained a major challenge. This Review
                      describes experimental preparations and methods for
                      recording and studying Ca2+ activity in astrocytes, focusing
                      on the analysis of Ca2+ signalling events in single
                      astrocytes and in astrocytic networks. The limitations of
                      existing experimental approaches and ongoing technical and
                      conceptual challenges in the interpretation of astrocytic
                      Ca2+ events and their spatio-temporal patterns are also
                      discussed.},
      subtyp        = {Review Article},
      keywords     = {Animals / Astrocytes: physiology / Brain: physiology /
                      Calcium Signaling: physiology / Cells, Cultured / Humans /
                      Neurons: physiology / Optical Imaging},
      cin          = {U Clinical Researchers - Bonn},
      ddc          = {570},
      cid          = {I:(DE-2719)7000001},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32873937},
      doi          = {10.1038/s41583-020-0361-8},
      url          = {https://pub.dzne.de/record/153437},
}