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024 7 _ |a 10.1038/s41583-020-0361-8
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041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Semyanov, Alexey
|0 0000-0002-6800-0942
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245 _ _ |a Making sense of astrocytic calcium signals — from acquisition to interpretation
260 _ _ |a London
|c 2020
|b Nature Publ. Group
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520 _ _ |a Astrocytes functionally interact with neurons and with other brain cells. Although not electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling that evolves in space and time within single astrocytes and across astrocytic networks. Decoding the physiological meaning of these dynamic changes in astrocytic Ca2+ activity has remained a major challenge. This Review describes experimental preparations and methods for recording and studying Ca2+ activity in astrocytes, focusing on the analysis of Ca2+ signalling events in single astrocytes and in astrocytic networks. The limitations of existing experimental approaches and ongoing technical and conceptual challenges in the interpretation of astrocytic Ca2+ events and their spatio-temporal patterns are also discussed.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Astrocytes: physiology
|2 MeSH
650 _ 2 |a Brain: physiology
|2 MeSH
650 _ 2 |a Calcium Signaling: physiology
|2 MeSH
650 _ 2 |a Cells, Cultured
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Optical Imaging
|2 MeSH
700 1 _ |a Henneberger, Christian
|0 P:(DE-2719)2811625
|b 1
|u dzne
700 1 _ |a Agarwal, Amit
|0 0000-0001-7948-4498
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773 _ _ |a 10.1038/s41583-020-0361-8
|g Vol. 21, no. 10, p. 551 - 564
|0 PERI:(DE-600)2028902-9
|n 10
|p 551 - 564
|t Nature reviews / Neuroscience
|v 21
|y 2020
|x 1471-0048
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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