TY  - JOUR
AU  - Schreiber, Frank
AU  - Garz, Cornelia
AU  - Heinze, Hans-Jochen
AU  - Petri, Susanne
AU  - Vielhaber, Stefan
AU  - Schreiber, Stefanie
TI  - Textural markers of ultrasonographic nerve alterations in amyotro phic lateral sclerosis
JO  - Muscle & nerve
VL  - 62
IS  - 5
SN  - 1097-4598
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DZNE-2020-01437
SP  - 601 - 610
PY  - 2020
AB  - Ultrasound has revealed cross‐sectional nerve area (CSA) reduction in amyotrophic lateral sclerosis (ALS), but little is known about the sonographic nerve texture beyond CSA alterations. In a large cohort of 177 ALS patients and 57 control subjects, we investigated the covariance and disease‐specific signature of several sonographic texture features of the median and ulnar nerves and their relationship to the patients’ clinical characteristics. ALS patients showed atrophic nerves, a loss of the intranerve structures’ echoic contrast, elevated coarseness, and a trend toward lower cluster shading compared with controls. A reduction in intranerve echoic contrast was related to longer disease duration and poorer functional status in ALS. Sonographic texture markers point toward a significant reorganization of the deep nerve microstructure in ALS. Future studies will be needed to further substantiate the markers’ potential to assess peripheral nerve alterations in ALS.
KW  - Aged
KW  - Amyotrophic Lateral Sclerosis: diagnostic imaging
KW  - Amyotrophic Lateral Sclerosis: pathology
KW  - Female
KW  - Forearm: innervation
KW  - Humans
KW  - Male
KW  - Median Nerve: diagnostic imaging
KW  - Median Nerve: pathology
KW  - Middle Aged
KW  - Ulnar Nerve: diagnostic imaging
KW  - Ulnar Nerve: pathology
KW  - Ultrasonography
KW  - Wit and Humor as Topic
LB  - PUB:(DE-HGF)16
C6  - pmid:32779757
DO  - DOI:10.1002/mus.27043
UR  - https://pub.dzne.de/record/153440
ER  -