Journal Article

DZNE-2020-01437

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Textural markers of ultrasonographic nerve alterations in amyotro phic lateral sclerosis

Schreiber, F. (First author)DZNE* ; Garz, C.DZNE* ; Heinze, H.-J.DZNE* ; Petri, S. ; Vielhaber, S.DZNE* ; Schreiber, S. (Last author)DZNE*

2020
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/mus.27043

Abstract: Ultrasound has revealed cross‐sectional nerve area (CSA) reduction in amyotrophic lateral sclerosis (ALS), but little is known about the sonographic nerve texture beyond CSA alterations. In a large cohort of 177 ALS patients and 57 control subjects, we investigated the covariance and disease‐specific signature of several sonographic texture features of the median and ulnar nerves and their relationship to the patients’ clinical characteristics. ALS patients showed atrophic nerves, a loss of the intranerve structures’ echoic contrast, elevated coarseness, and a trend toward lower cluster shading compared with controls. A reduction in intranerve echoic contrast was related to longer disease duration and poorer functional status in ALS. Sonographic texture markers point toward a significant reorganization of the deep nerve microstructure in ALS. Future studies will be needed to further substantiate the markers’ potential to assess peripheral nerve alterations in ALS.

Keyword(s): Aged (MeSH) ; Amyotrophic Lateral Sclerosis: diagnostic imaging (MeSH) ; Amyotrophic Lateral Sclerosis: pathology (MeSH) ; Female (MeSH) ; Forearm: innervation (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Median Nerve: diagnostic imaging (MeSH) ; Median Nerve: pathology (MeSH) ; Middle Aged (MeSH) ; Ulnar Nerve: diagnostic imaging (MeSH) ; Ulnar Nerve: pathology (MeSH) ; Ultrasonography (MeSH) ; Wit and Humor as Topic (MeSH)

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Contributing Institute(s):

1. U Clinical Researchers - Magdeburg (U Clinical Researchers - Magdeburg)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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