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@ARTICLE{Schreiber:153440,
      author       = {Schreiber, Frank and Garz, Cornelia and Heinze, Hans-Jochen
                      and Petri, Susanne and Vielhaber, Stefan and Schreiber,
                      Stefanie},
      title        = {{T}extural markers of ultrasonographic nerve alterations in
                      amyotro phic lateral sclerosis},
      journal      = {Muscle $\&$ nerve},
      volume       = {62},
      number       = {5},
      issn         = {1097-4598},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-01437},
      pages        = {601 - 610},
      year         = {2020},
      abstract     = {Ultrasound has revealed cross‐sectional nerve area (CSA)
                      reduction in amyotrophic lateral sclerosis (ALS), but little
                      is known about the sonographic nerve texture beyond CSA
                      alterations. In a large cohort of 177 ALS patients and 57
                      control subjects, we investigated the covariance and
                      disease‐specific signature of several sonographic texture
                      features of the median and ulnar nerves and their
                      relationship to the patients’ clinical characteristics.
                      ALS patients showed atrophic nerves, a loss of the
                      intranerve structures’ echoic contrast, elevated
                      coarseness, and a trend toward lower cluster shading
                      compared with controls. A reduction in intranerve echoic
                      contrast was related to longer disease duration and poorer
                      functional status in ALS. Sonographic texture markers point
                      toward a significant reorganization of the deep nerve
                      microstructure in ALS. Future studies will be needed to
                      further substantiate the markers’ potential to assess
                      peripheral nerve alterations in ALS.},
      keywords     = {Aged / Amyotrophic Lateral Sclerosis: diagnostic imaging /
                      Amyotrophic Lateral Sclerosis: pathology / Female / Forearm:
                      innervation / Humans / Male / Median Nerve: diagnostic
                      imaging / Median Nerve: pathology / Middle Aged / Ulnar
                      Nerve: diagnostic imaging / Ulnar Nerve: pathology /
                      Ultrasonography / Wit and Humor as Topic},
      cin          = {U Clinical Researchers - Magdeburg / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)7000000 / I:(DE-2719)5000006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32779757},
      doi          = {10.1002/mus.27043},
      url          = {https://pub.dzne.de/record/153440},
}