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001     153440
005     20240425115930.0
024 7 _ |a 10.1002/mus.27043
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024 7 _ |a 0148-639X
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024 7 _ |a 1097-4598
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037 _ _ |a DZNE-2020-01437
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Schreiber, Frank
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245 _ _ |a Textural markers of ultrasonographic nerve alterations in amyotro phic lateral sclerosis
260 _ _ |a New York, NY [u.a.]
|c 2020
|b Wiley
336 7 _ |a article
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520 _ _ |a Ultrasound has revealed cross‐sectional nerve area (CSA) reduction in amyotrophic lateral sclerosis (ALS), but little is known about the sonographic nerve texture beyond CSA alterations. In a large cohort of 177 ALS patients and 57 control subjects, we investigated the covariance and disease‐specific signature of several sonographic texture features of the median and ulnar nerves and their relationship to the patients’ clinical characteristics. ALS patients showed atrophic nerves, a loss of the intranerve structures’ echoic contrast, elevated coarseness, and a trend toward lower cluster shading compared with controls. A reduction in intranerve echoic contrast was related to longer disease duration and poorer functional status in ALS. Sonographic texture markers point toward a significant reorganization of the deep nerve microstructure in ALS. Future studies will be needed to further substantiate the markers’ potential to assess peripheral nerve alterations in ALS.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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588 _ _ |a Dataset connected to CrossRef
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: diagnostic imaging
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: pathology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Forearm: innervation
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Median Nerve: diagnostic imaging
|2 MeSH
650 _ 2 |a Median Nerve: pathology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Ulnar Nerve: diagnostic imaging
|2 MeSH
650 _ 2 |a Ulnar Nerve: pathology
|2 MeSH
650 _ 2 |a Ultrasonography
|2 MeSH
650 _ 2 |a Wit and Humor as Topic
|2 MeSH
700 1 _ |a Garz, Cornelia
|0 P:(DE-2719)2813207
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700 1 _ |a Heinze, Hans-Jochen
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700 1 _ |a Petri, Susanne
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700 1 _ |a Vielhaber, Stefan
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700 1 _ |a Schreiber, Stefanie
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773 _ _ |a 10.1002/mus.27043
|g Vol. 62, no. 5, p. 601 - 610
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|n 5
|p 601 - 610
|t Muscle & nerve
|v 62
|y 2020
|x 1097-4598
856 4 _ |u https://onlinelibrary.wiley.com/doi/full/10.1002/mus.27043
856 4 _ |u https://pub.dzne.de/record/153440/files/DZNE-2020-01437.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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