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000154186 0247_ $$2doi$$a10.1016/j.mad.2020.111327
000154186 0247_ $$2ISSN$$a0047-6374
000154186 0247_ $$2ISSN$$a1872-6216
000154186 037__ $$aDZNE-2021-00048
000154186 041__ $$aEnglish
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000154186 1001_ $$0P:(DE-2719)2812559$$aLountzi, Dimitra$$b0$$eFirst author$$udzne
000154186 245__ $$aEffects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice
000154186 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000154186 520__ $$aExperiments using heterochronic parabionts, i.e. young and old animals connected surgically and hence developing a shared circulation, have shown that blood-borne factors, transferred from young to old mice and vice versa, play a role in influencing a range of health outcomes associated with advanced age. Previous work has explored the contributory role of plasma-derived factors in mediating such parabiotic effects, including those on aging-associated neural and behavioural impairments. Here, we wanted to identify possible influences that blood-borne cellular factors may have on age-related behavioural phenotypes. Towards this end, we subjected old BALB/c H-2d mice to repetitive non-myeloablative bone marrow transplants (BMT) from young donor animals and assessed effects on behaviour and cognition. We detected expected age-related alterations in our behavioural assays but did not discern any obvious differences between old BMT mice and old control animals. Our study represents the first to look at possible behavioural and cognitive effects of heterochronic, non-myeloablative BMT. Future work should extend this study by including additional behavioural tests in the analysis, addressing whether beneficial effects of BMT may be detectable on other genetic backgrounds and reconciling our findings with those achieved by myeloablative BMT.
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000154186 588__ $$aDataset connected to CrossRef
000154186 650_2 $$2MeSH$$aAging
000154186 650_2 $$2MeSH$$aAllografts
000154186 650_2 $$2MeSH$$aAnimals
000154186 650_2 $$2MeSH$$aBehavior, Animal
000154186 650_2 $$2MeSH$$aBone Marrow Transplantation
000154186 650_2 $$2MeSH$$aMice
000154186 650_2 $$2MeSH$$aMice, Inbred BALB C
000154186 7001_ $$0P:(DE-2719)2810479$$aHenzel, Kristin$$b1$$udzne
000154186 7001_ $$aJazbec, Katerina$$b2
000154186 7001_ $$0P:(DE-2719)2158358$$aBano, Daniele$$b3$$udzne
000154186 7001_ $$0P:(DE-2719)2421562$$aKrauss, Sybille$$b4$$udzne
000154186 7001_ $$aRožman, Primož$$b5
000154186 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b6$$eLast author$$udzne
000154186 773__ $$0PERI:(DE-600)1502520-2$$a10.1016/j.mad.2020.111327$$gVol. 191, p. 111327 -$$p111327$$tMechanisms of ageing and development$$v191$$x0047-6374$$y2020
000154186 8564_ $$uhttps://www.sciencedirect.com/science/article/abs/pii/S0047637420301238?via%3Dihub
000154186 8564_ $$uhttps://pub.dzne.de/record/154186/files/DZNE-2021-00048_Restricted.pdf
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