Journal Article

DZNE-2021-00048

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice

Lountzi, D. (First author)DZNE* ; Henzel, K.DZNE* ; Jazbec, K. ; Bano, D.DZNE* ; Krauss, S.DZNE* ; Rožman, P. ; Ehninger, D. (Last author)DZNE*

2020
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.mad.2020.111327

Abstract: Experiments using heterochronic parabionts, i.e. young and old animals connected surgically and hence developing a shared circulation, have shown that blood-borne factors, transferred from young to old mice and vice versa, play a role in influencing a range of health outcomes associated with advanced age. Previous work has explored the contributory role of plasma-derived factors in mediating such parabiotic effects, including those on aging-associated neural and behavioural impairments. Here, we wanted to identify possible influences that blood-borne cellular factors may have on age-related behavioural phenotypes. Towards this end, we subjected old BALB/c H-2d mice to repetitive non-myeloablative bone marrow transplants (BMT) from young donor animals and assessed effects on behaviour and cognition. We detected expected age-related alterations in our behavioural assays but did not discern any obvious differences between old BMT mice and old control animals. Our study represents the first to look at possible behavioural and cognitive effects of heterochronic, non-myeloablative BMT. Future work should extend this study by including additional behavioural tests in the analysis, addressing whether beneficial effects of BMT may be detectable on other genetic backgrounds and reconciling our findings with those achieved by myeloablative BMT.

Keyword(s): Aging (MeSH) ; Allografts (MeSH) ; Animals (MeSH) ; Behavior, Animal (MeSH) ; Bone Marrow Transplantation (MeSH) ; Mice (MeSH) ; Mice, Inbred BALB C (MeSH)

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Contributing Institute(s):

1. Aging and Neurodegeneration (AG Bano)
2. Regulatory RNA-protein interaction in neurodegenerative diseases (AG Krauß)
3. Translational Biogerontology (AG Ehninger)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)
2. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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