TY  - JOUR
AU  - Lountzi, Dimitra
AU  - Henzel, Kristin
AU  - Jazbec, Katerina
AU  - Bano, Daniele
AU  - Krauss, Sybille
AU  - Rožman, Primož
AU  - Ehninger, Dan
TI  - Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice
JO  - Mechanisms of ageing and development
VL  - 191
SN  - 0047-6374
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2021-00048
SP  - 111327
PY  - 2020
AB  - Experiments using heterochronic parabionts, i.e. young and old animals connected surgically and hence developing a shared circulation, have shown that blood-borne factors, transferred from young to old mice and vice versa, play a role in influencing a range of health outcomes associated with advanced age. Previous work has explored the contributory role of plasma-derived factors in mediating such parabiotic effects, including those on aging-associated neural and behavioural impairments. Here, we wanted to identify possible influences that blood-borne cellular factors may have on age-related behavioural phenotypes. Towards this end, we subjected old BALB/c H-2d mice to repetitive non-myeloablative bone marrow transplants (BMT) from young donor animals and assessed effects on behaviour and cognition. We detected expected age-related alterations in our behavioural assays but did not discern any obvious differences between old BMT mice and old control animals. Our study represents the first to look at possible behavioural and cognitive effects of heterochronic, non-myeloablative BMT. Future work should extend this study by including additional behavioural tests in the analysis, addressing whether beneficial effects of BMT may be detectable on other genetic backgrounds and reconciling our findings with those achieved by myeloablative BMT.
KW  - Aging
KW  - Allografts
KW  - Animals
KW  - Behavior, Animal
KW  - Bone Marrow Transplantation
KW  - Mice
KW  - Mice, Inbred BALB C
LB  - PUB:(DE-HGF)16
C6  - pmid:32814083
DO  - DOI:10.1016/j.mad.2020.111327
UR  - https://pub.dzne.de/record/154186
ER  -