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@ARTICLE{Lountzi:154186,
      author       = {Lountzi, Dimitra and Henzel, Kristin and Jazbec, Katerina
                      and Bano, Daniele and Krauss, Sybille and Rožman, Primož
                      and Ehninger, Dan},
      title        = {{E}ffects of heterochronic, non-myeloablative bone marrow
                      transplantation on age-related behavioural changes in mice},
      journal      = {Mechanisms of ageing and development},
      volume       = {191},
      issn         = {0047-6374},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2021-00048},
      pages        = {111327},
      year         = {2020},
      abstract     = {Experiments using heterochronic parabionts, i.e. young and
                      old animals connected surgically and hence developing a
                      shared circulation, have shown that blood-borne factors,
                      transferred from young to old mice and vice versa, play a
                      role in influencing a range of health outcomes associated
                      with advanced age. Previous work has explored the
                      contributory role of plasma-derived factors in mediating
                      such parabiotic effects, including those on aging-associated
                      neural and behavioural impairments. Here, we wanted to
                      identify possible influences that blood-borne cellular
                      factors may have on age-related behavioural phenotypes.
                      Towards this end, we subjected old BALB/c H-2d mice to
                      repetitive non-myeloablative bone marrow transplants (BMT)
                      from young donor animals and assessed effects on behaviour
                      and cognition. We detected expected age-related alterations
                      in our behavioural assays but did not discern any obvious
                      differences between old BMT mice and old control animals.
                      Our study represents the first to look at possible
                      behavioural and cognitive effects of heterochronic,
                      non-myeloablative BMT. Future work should extend this study
                      by including additional behavioural tests in the analysis,
                      addressing whether beneficial effects of BMT may be
                      detectable on other genetic backgrounds and reconciling our
                      findings with those achieved by myeloablative BMT.},
      keywords     = {Aging / Allografts / Animals / Behavior, Animal / Bone
                      Marrow Transplantation / Mice / Mice, Inbred BALB C},
      cin          = {AG Bano / AG Krauß / AG Ehninger},
      ddc          = {610},
      cid          = {I:(DE-2719)1013003 / I:(DE-2719)1011006 /
                      I:(DE-2719)1013005},
      pnm          = {341 - Molecular Signaling (POF3-341) / 342 - Disease
                      Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-341 / G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32814083},
      doi          = {10.1016/j.mad.2020.111327},
      url          = {https://pub.dzne.de/record/154186},
}