Home > Publications Database > Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice > print

001     154186
005     20240219124743.0
024 7 _ |a pmid:32814083
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024 7 _ |a 10.1016/j.mad.2020.111327
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024 7 _ |a 0047-6374
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024 7 _ |a 1872-6216
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037 _ _ |a DZNE-2021-00048
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lountzi, Dimitra
|0 P:(DE-2719)2812559
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|e First author
|u dzne
245 _ _ |a Effects of heterochronic, non-myeloablative bone marrow transplantation on age-related behavioural changes in mice
260 _ _ |a Amsterdam [u.a.]
|c 2020
|b Elsevier Science
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Experiments using heterochronic parabionts, i.e. young and old animals connected surgically and hence developing a shared circulation, have shown that blood-borne factors, transferred from young to old mice and vice versa, play a role in influencing a range of health outcomes associated with advanced age. Previous work has explored the contributory role of plasma-derived factors in mediating such parabiotic effects, including those on aging-associated neural and behavioural impairments. Here, we wanted to identify possible influences that blood-borne cellular factors may have on age-related behavioural phenotypes. Towards this end, we subjected old BALB/c H-2d mice to repetitive non-myeloablative bone marrow transplants (BMT) from young donor animals and assessed effects on behaviour and cognition. We detected expected age-related alterations in our behavioural assays but did not discern any obvious differences between old BMT mice and old control animals. Our study represents the first to look at possible behavioural and cognitive effects of heterochronic, non-myeloablative BMT. Future work should extend this study by including additional behavioural tests in the analysis, addressing whether beneficial effects of BMT may be detectable on other genetic backgrounds and reconciling our findings with those achieved by myeloablative BMT.
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588 _ _ |a Dataset connected to CrossRef
650 _ 2 |a Aging
|2 MeSH
650 _ 2 |a Allografts
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Behavior, Animal
|2 MeSH
650 _ 2 |a Bone Marrow Transplantation
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred BALB C
|2 MeSH
700 1 _ |a Henzel, Kristin
|0 P:(DE-2719)2810479
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|u dzne
700 1 _ |a Jazbec, Katerina
|b 2
700 1 _ |a Bano, Daniele
|0 P:(DE-2719)2158358
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700 1 _ |a Krauss, Sybille
|0 P:(DE-2719)2421562
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700 1 _ |a Rožman, Primož
|b 5
700 1 _ |a Ehninger, Dan
|0 P:(DE-2719)2289209
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|e Last author
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773 _ _ |a 10.1016/j.mad.2020.111327
|g Vol. 191, p. 111327 -
|0 PERI:(DE-600)1502520-2
|p 111327
|t Mechanisms of ageing and development
|v 191
|y 2020
|x 0047-6374
856 4 _ |u https://www.sciencedirect.com/science/article/abs/pii/S0047637420301238?via%3Dihub
856 4 _ |u https://pub.dzne.de/record/154186/files/DZNE-2021-00048_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/154186/files/DZNE-2021-00048_Restricted.pdf?subformat=pdfa
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