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000154273 0247_ $$2doi$$a10.1002/alz.12163
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000154273 0247_ $$2ISSN$$a1552-5279
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000154273 037__ $$aDZNE-2021-00127
000154273 041__ $$aEnglish
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000154273 1001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b0$$eFirst author$$udzne
000154273 245__ $$aPrediction of dementia of Alzheimer type by different types of subjective cognitive decline.
000154273 260__ $$aHoboken, NJ$$bWiley$$c2020
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000154273 520__ $$aSubjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT).We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow-up).82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow-up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow-up at the expense of low sensitivity.Different SCD subtypes were either sensitive or specific for future all-cause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population.
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000154273 650_7 $$2Other$$aAlzheimer's disease
000154273 650_7 $$2Other$$anegative predictive value
000154273 650_7 $$2Other$$apositive predictive value
000154273 650_7 $$2Other$$asubjective cognitive decline
000154273 650_2 $$2MeSH$$aAlzheimer Disease: classification
000154273 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000154273 650_2 $$2MeSH$$aAlzheimer Disease: epidemiology
000154273 650_2 $$2MeSH$$aAnxiety: psychology
000154273 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000154273 650_2 $$2MeSH$$aCognitive Dysfunction: epidemiology
000154273 650_2 $$2MeSH$$aGermany: epidemiology
000154273 650_2 $$2MeSH$$aHumans
000154273 650_2 $$2MeSH$$aLongitudinal Studies
000154273 650_2 $$2MeSH$$aNeuropsychological Tests: statistics & numerical data
000154273 650_2 $$2MeSH$$aPredictive Value of Tests
000154273 650_2 $$2MeSH$$aPrevalence
000154273 650_2 $$2MeSH$$aSelf Report
000154273 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b1$$udzne
000154273 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b2$$udzne
000154273 7001_ $$aBickel, Horst$$b3
000154273 7001_ $$aBrettschneider, Christian$$b4
000154273 7001_ $$aFuchs, Angela$$b5
000154273 7001_ $$aKaduszkiewicz, Hanna$$b6
000154273 7001_ $$aKönig, Hans-Helmut$$b7
000154273 7001_ $$aMallon, Tina$$b8
000154273 7001_ $$aMamone, Silke$$b9
000154273 7001_ $$aPabst, Alexander$$b10
000154273 7001_ $$aPentzek, Michael$$b11
000154273 7001_ $$aRoehr, Susanne$$b12
000154273 7001_ $$aWeeg, Dagmar$$b13
000154273 7001_ $$aJochen, Werle$$b14
000154273 7001_ $$aWeyerer, Siegfried$$b15
000154273 7001_ $$aWiese, Birgitt$$b16
000154273 7001_ $$0P:(DE-HGF)0$$aMaier, Wolfgang$$b17
000154273 7001_ $$aScherer, Martin$$b18
000154273 7001_ $$aRiedel-Heller, Steffi$$b19
000154273 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b20$$eLast author$$udzne
000154273 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12163$$gVol. 16, no. 12, p. 1745 - 1749$$n12$$p1745 - 1749$$tAlzheimer's and dementia$$v16$$x1552-5279$$y2020
000154273 8564_ $$uhttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12163
000154273 8564_ $$uhttps://pub.dzne.de/record/154273/files/DZNE-2021-00127_Restricted.pdf
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000154273 9201_ $$0I:(DE-2719)1011102$$kAG Jessen$$lClinical Alzheimer’s Disease Research$$x0
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