Journal Article

DZNE-2021-00127

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prediction of dementia of Alzheimer type by different types of subjective cognitive decline.

Jessen, F. (First author)DZNE* ; Kleineidam, L.DZNE* ; Wolfsgruber, S.DZNE* ; Bickel, H. ; Brettschneider, C. ; Fuchs, A. ; Kaduszkiewicz, H. ; König, H.-H. ; Mallon, T. ; Mamone, S. ; Pabst, A. ; Pentzek, M. ; Roehr, S. ; Weeg, D. ; Jochen, W. ; Weyerer, S. ; Wiese, B. ; Maier, W. ; Scherer, M. ; Riedel-Heller, S. ; Wagner, M. (Last author)DZNE*

2020
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.12163

Abstract: Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT).We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow-up).82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow-up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow-up at the expense of low sensitivity.Different SCD subtypes were either sensitive or specific for future all-cause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population.

Keyword(s): Alzheimer Disease: classification (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: epidemiology (MeSH) ; Anxiety: psychology (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Cognitive Dysfunction: epidemiology (MeSH) ; Germany: epidemiology (MeSH) ; Humans (MeSH) ; Longitudinal Studies (MeSH) ; Neuropsychological Tests: statistics & numerical data (MeSH) ; Predictive Value of Tests (MeSH) ; Prevalence (MeSH) ; Self Report (MeSH) ; Alzheimer's disease ; negative predictive value ; positive predictive value ; subjective cognitive decline

Note: ISSN 1552-5279 not unique: **3 hits**.

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Contributing Institute(s):

1. Clinical Alzheimer’s Disease Research (AG Jessen)
2. Neuropsychology (AG Wagner)
3. U Clinical Researchers - Bonn (U Clinical Researchers - Bonn)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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