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000154294 041__ $$aEnglish
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000154294 1001_ $$0P:(DE-2719)9000797$$aUlbrich, Philipp$$b0$$eFirst author$$udzne
000154294 245__ $$aInterplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases.
000154294 260__ $$aOxford [u.a.]$$bWiley$$c2021
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000154294 520__ $$aVascular damage, central nervous system (CNS) injury, seizure or even psychological stress may trigger activation of microglia and infiltration of other immune cells, accompanied by high levels of expression and activity of extracellular proteases, such as matrix metalloproteinases (MMPs), and degradation/remodelling of the perivascular and perineuronal extracellular matrix (ECM). This acute response is followed by the recovery/chronic phase, during which the activation of astrocytes leads to the upregulated synthesis of ECM molecules, which, in combination with elevated expression of tissue inhibitor of metalloproteinases (TIMP) proteins, increases the aggregation of ECM molecules. This biphasic dysregulation of local balance between extracellular proteases and the ECM activates multiple temporally overlapping signalling cascades, involving receptor-type protein tyrosine phosphatases, integrins, Toll-like receptors, cell adhesion molecules, and ion channels, resulting in impaired synaptic plasticity and cognition. An additional level of complexity is related to the leakage of blood plasma proteins, such as fibrinogen, and the diffusion of perivascularly overproduced MMPs, TIMPs and ECM molecules into the CNS parenchyma, leading to diverse effects on neurons and incorporation of these molecules into the interstitial neural ECM. This review aims to outline these complex common mechanisms in stroke, CNS injury, depression, epilepsy, multiple sclerosis and cerebral small vessel disease and to discuss translational strategies to advance the development of new therapies for these neurological and psychiatric diseases.
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000154294 650_7 $$2Other$$acerebral small vessel disease
000154294 650_7 $$2Other$$aperineuronal extracellular matrix
000154294 650_7 $$2Other$$aperivascular extracellular matrix
000154294 650_7 $$2Other$$astroke
000154294 650_2 $$2MeSH$$aAstrocytes
000154294 650_2 $$2MeSH$$aExtracellular Matrix
000154294 650_2 $$2MeSH$$aHumans
000154294 650_2 $$2MeSH$$aMatrix Metalloproteinases
000154294 650_2 $$2MeSH$$aMental Disorders
000154294 650_2 $$2MeSH$$aNervous System Diseases
000154294 650_2 $$2MeSH$$aNeurons
000154294 650_2 $$2MeSH$$aTissue Inhibitor of Metalloproteinases
000154294 7001_ $$0P:(DE-2719)2814351$$aKhoshneviszadeh, Mashima$$b1$$udzne
000154294 7001_ $$0P:(DE-2719)2813348$$aJandke, Solveig$$b2$$udzne
000154294 7001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefanie$$b3$$udzne
000154294 7001_ $$0P:(DE-2719)2810577$$aDityatev, Alexander$$b4$$eLast author$$udzne
000154294 773__ $$0PERI:(DE-600)2005178-5$$a10.1111/ejn.14887$$gp. ejn.14887$$n12$$p3811-3830$$tEuropean journal of neuroscience$$v53$$x1460-9568$$y2021
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