Journal Article

DZNE-2021-00148

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases.

Ulbrich, P. (First author)DZNE* ; Khoshneviszadeh, M.DZNE* ; Jandke, S.DZNE* ; Schreiber, S.DZNE* ; Dityatev, A. (Last author)DZNE*

2021
Wiley Oxford [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1111/ejn.14887

Abstract: Vascular damage, central nervous system (CNS) injury, seizure or even psychological stress may trigger activation of microglia and infiltration of other immune cells, accompanied by high levels of expression and activity of extracellular proteases, such as matrix metalloproteinases (MMPs), and degradation/remodelling of the perivascular and perineuronal extracellular matrix (ECM). This acute response is followed by the recovery/chronic phase, during which the activation of astrocytes leads to the upregulated synthesis of ECM molecules, which, in combination with elevated expression of tissue inhibitor of metalloproteinases (TIMP) proteins, increases the aggregation of ECM molecules. This biphasic dysregulation of local balance between extracellular proteases and the ECM activates multiple temporally overlapping signalling cascades, involving receptor-type protein tyrosine phosphatases, integrins, Toll-like receptors, cell adhesion molecules, and ion channels, resulting in impaired synaptic plasticity and cognition. An additional level of complexity is related to the leakage of blood plasma proteins, such as fibrinogen, and the diffusion of perivascularly overproduced MMPs, TIMPs and ECM molecules into the CNS parenchyma, leading to diverse effects on neurons and incorporation of these molecules into the interstitial neural ECM. This review aims to outline these complex common mechanisms in stroke, CNS injury, depression, epilepsy, multiple sclerosis and cerebral small vessel disease and to discuss translational strategies to advance the development of new therapies for these neurological and psychiatric diseases.

Keyword(s): Astrocytes (MeSH) ; Extracellular Matrix (MeSH) ; Humans (MeSH) ; Matrix Metalloproteinases (MeSH) ; Mental Disorders (MeSH) ; Nervous System Diseases (MeSH) ; Neurons (MeSH) ; Tissue Inhibitor of Metalloproteinases (MeSH) ; cerebral small vessel disease ; perineuronal extracellular matrix ; perivascular extracellular matrix ; stroke

Note: ISSN 1460-9568 not unique: **3 hits**.

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Contributing Institute(s):

1. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)
2. Pathophysiology of Dementia (AG Reymann)
3. Molecular Neuroplasticity (AG Dityatev)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2021

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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