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@ARTICLE{Ulbrich:154294,
      author       = {Ulbrich, Philipp and Khoshneviszadeh, Mashima and Jandke,
                      Solveig and Schreiber, Stefanie and Dityatev, Alexander},
      title        = {{I}nterplay between perivascular and perineuronal
                      extracellular matrix remodelling in neurological and
                      psychiatric diseases.},
      journal      = {European journal of neuroscience},
      volume       = {53},
      number       = {12},
      issn         = {1460-9568},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00148},
      pages        = {3811-3830},
      year         = {2021},
      note         = {ISSN 1460-9568 not unique: **3 hits**.},
      abstract     = {Vascular damage, central nervous system (CNS) injury,
                      seizure or even psychological stress may trigger activation
                      of microglia and infiltration of other immune cells,
                      accompanied by high levels of expression and activity of
                      extracellular proteases, such as matrix metalloproteinases
                      (MMPs), and degradation/remodelling of the perivascular and
                      perineuronal extracellular matrix (ECM). This acute response
                      is followed by the recovery/chronic phase, during which the
                      activation of astrocytes leads to the upregulated synthesis
                      of ECM molecules, which, in combination with elevated
                      expression of tissue inhibitor of metalloproteinases (TIMP)
                      proteins, increases the aggregation of ECM molecules. This
                      biphasic dysregulation of local balance between
                      extracellular proteases and the ECM activates multiple
                      temporally overlapping signalling cascades, involving
                      receptor-type protein tyrosine phosphatases, integrins,
                      Toll-like receptors, cell adhesion molecules, and ion
                      channels, resulting in impaired synaptic plasticity and
                      cognition. An additional level of complexity is related to
                      the leakage of blood plasma proteins, such as fibrinogen,
                      and the diffusion of perivascularly overproduced MMPs, TIMPs
                      and ECM molecules into the CNS parenchyma, leading to
                      diverse effects on neurons and incorporation of these
                      molecules into the interstitial neural ECM. This review aims
                      to outline these complex common mechanisms in stroke, CNS
                      injury, depression, epilepsy, multiple sclerosis and
                      cerebral small vessel disease and to discuss translational
                      strategies to advance the development of new therapies for
                      these neurological and psychiatric diseases.},
      keywords     = {Astrocytes / Extracellular Matrix / Humans / Matrix
                      Metalloproteinases / Mental Disorders / Nervous System
                      Diseases / Neurons / Tissue Inhibitor of Metalloproteinases
                      / cerebral small vessel disease (Other) / perineuronal
                      extracellular matrix (Other) / perivascular extracellular
                      matrix (Other) / stroke (Other)},
      cin          = {AG Schreiber / AG Reymann / AG Dityatev},
      ddc          = {610},
      cid          = {I:(DE-2719)1310010 / I:(DE-2719)1310005 /
                      I:(DE-2719)1310007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 351 -
                      Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32594588},
      doi          = {10.1111/ejn.14887},
      url          = {https://pub.dzne.de/record/154294},
}