TY  - JOUR
AU  - Al Shweiki, Mhd Rami
AU  - Oeckl, Patrick
AU  - Pachollek, Adrian
AU  - Steinacker, Petra
AU  - Barschke, Peggy
AU  - Halbgebauer, Steffen
AU  - Anderl-Straub, Sarah
AU  - Lewerenz, Jan
AU  - Ludolph, Albert C
AU  - Bernhard Landwehrmeyer, Georg
AU  - Otto, Markus
TI  - Cerebrospinal Fluid Levels of Prodynorphin-Derived Peptides are Decreased in Huntington's Disease.
JO  - Movement disorders
VL  - 36
IS  - 2
SN  - 1531-8257
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2021-00181
SP  - 492 - 497
PY  - 2021
N1  - ISSN 1531-8257 not unique: **3 hits**.
AB  - Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by a selective loss of striatal medium spiny projection neurons (MSNs). Prodynorphin (PDYN) is enriched in a subpopulation of striatal MSNs. Postmortem brains of HD patients and rodent models have been demonstrated to have reduced levels of PDYN transcripts and the neuropeptide dynorphin.Given the unmet need for novel pharmacodynamic HD biomarkers in the context of experimental huntingtin (htt)-lowering therapies, we investigated the levels of PDYN-derived peptides and neurofilament light (NfL) chain in the cerebrospinal fluid (CSF) from HD patients (n = 16), matched controls (n = 55), and patients with other neurodegenerative disorders (n = 70).PDYN-derived peptide levels were found to be substantially decreased in HD patients (P < 0.0001 in comparison to controls), whereas the NfL levels were elevated in all neurodegenerative disorders.Our study suggests decreased PDYN-derived peptide levels in the CSF as a more specific biomarker for HD in comparison to NfL. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
KW  - Corpus Striatum: metabolism
KW  - Enkephalins
KW  - Humans
KW  - Huntingtin Protein
KW  - Huntington Disease
KW  - Neurofilament Proteins
KW  - Peptides
KW  - Protein Precursors
KW  - neurofilaments; prodynorphin; biomarker; Huntingtonʼs disease; frontotemporal dementia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33006791
DO  - DOI:10.1002/mds.28300
UR  - https://pub.dzne.de/record/154327
ER  -