Journal Article

DZNE-2021-00181

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cerebrospinal Fluid Levels of Prodynorphin-Derived Peptides are Decreased in Huntington's Disease.

Al Shweiki, M. R. ; Oeckl, P. ; Pachollek, A. ; Steinacker, P. ; Barschke, P. ; Halbgebauer, S. ; Anderl-Straub, S. ; Lewerenz, J. ; Ludolph, A. C.DZNE* ; Bernhard Landwehrmeyer, G. ; Otto, M. (Corresponding author)

2021
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.28300

Abstract: Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by a selective loss of striatal medium spiny projection neurons (MSNs). Prodynorphin (PDYN) is enriched in a subpopulation of striatal MSNs. Postmortem brains of HD patients and rodent models have been demonstrated to have reduced levels of PDYN transcripts and the neuropeptide dynorphin.Given the unmet need for novel pharmacodynamic HD biomarkers in the context of experimental huntingtin (htt)-lowering therapies, we investigated the levels of PDYN-derived peptides and neurofilament light (NfL) chain in the cerebrospinal fluid (CSF) from HD patients (n = 16), matched controls (n = 55), and patients with other neurodegenerative disorders (n = 70).PDYN-derived peptide levels were found to be substantially decreased in HD patients (P < 0.0001 in comparison to controls), whereas the NfL levels were elevated in all neurodegenerative disorders.Our study suggests decreased PDYN-derived peptide levels in the CSF as a more specific biomarker for HD in comparison to NfL. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Corpus Striatum: metabolism (MeSH) ; Enkephalins (MeSH) ; Humans (MeSH) ; Huntingtin Protein (MeSH) ; Huntington Disease (MeSH) ; Neurofilament Proteins (MeSH) ; Peptides (MeSH) ; Protein Precursors (MeSH) ; neurofilaments; prodynorphin; biomarker; Huntingtonʼs disease; frontotemporal dementia

Note: ISSN 1531-8257 not unique: **3 hits**.

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Contributing Institute(s):

1. Clinical Study Center Ulm (Clinical Study Center Ulm)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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