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000154364 0247_ $$2doi$$a10.1016/j.conb.2020.04.006
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000154364 037__ $$aDZNE-2021-00217
000154364 041__ $$aEnglish
000154364 082__ $$a610
000154364 1001_ $$0P:(DE-HGF)0$$aWolfes, Anne C$$b0
000154364 245__ $$aThe diversity of synaptotagmin isoforms.
000154364 260__ $$aPhiladelphia, Pa.$$bCurrent Biology$$c2020
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000154364 520__ $$aThe synaptotagmin family of molecules is known for regulating calcium-dependent membrane fusion events. Mice and humans express 17 synaptotagmin isoforms, where most studies have focused on isoforms 1, 2, and 7, which are involved in synaptic vesicle exocytosis. Recent work has highlighted how brain function relies on additional isoforms, with roles in postsynaptic receptor endocytosis, vesicle trafficking, membrane repair, synaptic plasticity, and protection against neurodegeneration, for example, in addition to the traditional concept of synaptotagmin-mediated neurotransmitter release - in neurons as well as glia, and at different timepoints. In fact, it is not uncommon for the same isoform to feature several splice isoforms, form homo- and heterodimers, and function in different subcellular locations and cell types. This review aims to highlight the diversity of synaptotagmins, offers a concise summary of key findings on all isoforms, and discusses different ways of grouping these.
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000154364 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000154364 650_7 $$2NLM Chemicals$$aProtein Isoforms
000154364 650_7 $$2NLM Chemicals$$aSynaptotagmin I
000154364 650_7 $$0134193-27-4$$2NLM Chemicals$$aSynaptotagmins
000154364 650_7 $$0SY7Q814VUP$$2NLM Chemicals$$aCalcium
000154364 650_2 $$2MeSH$$aAnimals
000154364 650_2 $$2MeSH$$aCalcium: metabolism
000154364 650_2 $$2MeSH$$aExocytosis
000154364 650_2 $$2MeSH$$aHumans
000154364 650_2 $$2MeSH$$aMembrane Fusion
000154364 650_2 $$2MeSH$$aMice
000154364 650_2 $$2MeSH$$aNerve Tissue Proteins: metabolism
000154364 650_2 $$2MeSH$$aProtein Isoforms: genetics
000154364 650_2 $$2MeSH$$aProtein Isoforms: metabolism
000154364 650_2 $$2MeSH$$aSynaptotagmin I
000154364 650_2 $$2MeSH$$aSynaptotagmins: genetics
000154364 7001_ $$0P:(DE-2719)2812587$$aDean, Camin$$b1$$eLast author$$udzne
000154364 773__ $$0PERI:(DE-600)2013035-1$$a10.1016/j.conb.2020.04.006$$gVol. 63, p. 198 - 209$$p198 - 209$$tCurrent opinion in neurobiology$$v63$$x0959-4388$$y2020
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