Journal Article (Review Article)

DZNE-2021-00217

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The diversity of synaptotagmin isoforms.

Wolfes, A. C. ; Dean, C. (Last author)DZNE*

2020
Current Biology Philadelphia, Pa.

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Please use a persistent id in citations: doi:10.1016/j.conb.2020.04.006

Abstract: The synaptotagmin family of molecules is known for regulating calcium-dependent membrane fusion events. Mice and humans express 17 synaptotagmin isoforms, where most studies have focused on isoforms 1, 2, and 7, which are involved in synaptic vesicle exocytosis. Recent work has highlighted how brain function relies on additional isoforms, with roles in postsynaptic receptor endocytosis, vesicle trafficking, membrane repair, synaptic plasticity, and protection against neurodegeneration, for example, in addition to the traditional concept of synaptotagmin-mediated neurotransmitter release - in neurons as well as glia, and at different timepoints. In fact, it is not uncommon for the same isoform to feature several splice isoforms, form homo- and heterodimers, and function in different subcellular locations and cell types. This review aims to highlight the diversity of synaptotagmins, offers a concise summary of key findings on all isoforms, and discusses different ways of grouping these.

Keyword(s): Animals (MeSH) ; Calcium: metabolism (MeSH) ; Exocytosis (MeSH) ; Humans (MeSH) ; Membrane Fusion (MeSH) ; Mice (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Protein Isoforms: genetics (MeSH) ; Protein Isoforms: metabolism (MeSH) ; Synaptotagmin I (MeSH) ; Synaptotagmins: genetics (MeSH) ; Nerve Tissue Proteins ; Protein Isoforms ; Synaptotagmin I ; Synaptotagmins ; Calcium

Note: ISSN 0959-4388 not unique: **3 hits**.

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Contributing Institute(s):

1. Synaptic Dysfunction (AG Dean)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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