TY  - JOUR
AU  - Wolfes, Anne C
AU  - Dean, Camin
TI  - The diversity of synaptotagmin isoforms.
JO  - Current opinion in neurobiology
VL  - 63
SN  - 0959-4388
CY  - Philadelphia, Pa.
PB  - Current Biology
M1  - DZNE-2021-00217
SP  - 198 - 209
PY  - 2020
N1  - ISSN 0959-4388 not unique: **3 hits**.
AB  - The synaptotagmin family of molecules is known for regulating calcium-dependent membrane fusion events. Mice and humans express 17 synaptotagmin isoforms, where most studies have focused on isoforms 1, 2, and 7, which are involved in synaptic vesicle exocytosis. Recent work has highlighted how brain function relies on additional isoforms, with roles in postsynaptic receptor endocytosis, vesicle trafficking, membrane repair, synaptic plasticity, and protection against neurodegeneration, for example, in addition to the traditional concept of synaptotagmin-mediated neurotransmitter release - in neurons as well as glia, and at different timepoints. In fact, it is not uncommon for the same isoform to feature several splice isoforms, form homo- and heterodimers, and function in different subcellular locations and cell types. This review aims to highlight the diversity of synaptotagmins, offers a concise summary of key findings on all isoforms, and discusses different ways of grouping these.
KW  - Animals
KW  - Calcium: metabolism
KW  - Exocytosis
KW  - Humans
KW  - Membrane Fusion
KW  - Mice
KW  - Nerve Tissue Proteins: metabolism
KW  - Protein Isoforms: genetics
KW  - Protein Isoforms: metabolism
KW  - Synaptotagmin I
KW  - Synaptotagmins: genetics
KW  - Nerve Tissue Proteins (NLM Chemicals)
KW  - Protein Isoforms (NLM Chemicals)
KW  - Synaptotagmin I (NLM Chemicals)
KW  - Synaptotagmins (NLM Chemicals)
KW  - Calcium (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:32663762
DO  - DOI:10.1016/j.conb.2020.04.006
UR  - https://pub.dzne.de/record/154364
ER  -