TY  - JOUR
AU  - Markaki, Ioanna
AU  - Bergström, Sofia
AU  - Tsitsi, Panagiota
AU  - Remnestål, Julia
AU  - Månberg, Anna
AU  - Hertz, Ellen
AU  - Paslawski, Wojciech
AU  - Sorjonen, Kimmo
AU  - Uhlén, Mathias
AU  - Mangone, Graziella
AU  - Carvalho, Stephanie
AU  - Rascol, Olivier
AU  - Meissner, Wassilios G
AU  - Magnin, Eloi
AU  - Wüllner, Ullrich
AU  - Corvol, Jean-Christophe
AU  - Nilsson, Peter
AU  - Svenningsson, Per
TI  - Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
JO  - Movement disorders
VL  - 35
IS  - 11
SN  - 1531-8257
CY  - New York, NY
PB  - Wiley
M1  - DZNE-2021-00235
SP  - 2101 - 2106
PY  - 2020
N1  - ISSN 1531-8257 not unique: **3 hits**.
AB  - Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date.The aim of this study was to investigate CSF markers associated with cognition in early PD.A high-throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini-Mental State Examination.Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen-1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders.Kininogen-1 levels in CSF may serve as a marker of cognitive impairment in PD. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
KW  - Cognition Disorders: diagnosis
KW  - Cognition Disorders: etiology
KW  - Cognitive Dysfunction: etiology
KW  - Humans
KW  - Kininogens
KW  - Mental Status and Dementia Tests
KW  - Neuropsychological Tests
KW  - Parkinson Disease: complications
KW  - Parkinson's disease (Other)
KW  - cognition (Other)
KW  - kininogen-1 (Other)
KW  - neurodegeneration (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33179332
DO  - DOI:10.1002/mds.28192
UR  - https://pub.dzne.de/record/154382
ER  -