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@ARTICLE{Markaki:154382,
      author       = {Markaki, Ioanna and Bergström, Sofia and Tsitsi, Panagiota
                      and Remnestål, Julia and Månberg, Anna and Hertz, Ellen
                      and Paslawski, Wojciech and Sorjonen, Kimmo and Uhlén,
                      Mathias and Mangone, Graziella and Carvalho, Stephanie and
                      Rascol, Olivier and Meissner, Wassilios G and Magnin, Eloi
                      and Wüllner, Ullrich and Corvol, Jean-Christophe and
                      Nilsson, Peter and Svenningsson, Per},
      title        = {{C}erebrospinal {F}luid {L}evels of {K}ininogen-1
                      {I}ndicate {E}arly {C}ognitive {I}mpairment in {P}arkinson's
                      {D}isease.},
      journal      = {Movement disorders},
      volume       = {35},
      number       = {11},
      issn         = {1531-8257},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-00235},
      pages        = {2101 - 2106},
      year         = {2020},
      note         = {ISSN 1531-8257 not unique: **3 hits**.},
      abstract     = {Cognitive impairment is common in patients with PD. Core
                      markers of Alzheimer's dementia have been related also to PD
                      dementia, but no disease-specific signature to predict PD
                      dementia exists to date.The aim of this study was to
                      investigate CSF markers associated with cognition in early
                      PD.A high-throughput suspension bead array examined 216
                      proteins in CSF of 74 PD patients in the AETIONOMY project.
                      Cognitive function was assessed with Repeatable Battery for
                      the Assessment of the Neuropsychological Status, Montreal
                      Cognitive Assessment, and Mini-Mental State Examination.Of
                      69 patients with complete data, 34 had high (≥90) and 35
                      had low Repeatable Battery for the Assessment of the
                      Neuropsychological Status total score (<90). Of 14 proteins
                      in CSF that differed in levels between groups, increased
                      kininogen-1, validated with several antibodies, was
                      independently associated with lower Repeatable Battery for
                      the Assessment of the Neuropsychological Status and Montreal
                      Cognitive Assessment scores after adjustment for
                      confounders.Kininogen-1 levels in CSF may serve as a marker
                      of cognitive impairment in PD. © 2020 The Authors. Movement
                      Disorders published by Wiley Periodicals LLC on behalf of
                      International Parkinson and Movement Disorder Society.},
      keywords     = {Cognition Disorders: diagnosis / Cognition Disorders:
                      etiology / Cognitive Dysfunction: etiology / Humans /
                      Kininogens / Mental Status and Dementia Tests /
                      Neuropsychological Tests / Parkinson Disease: complications
                      / Parkinson's disease (Other) / cognition (Other) /
                      kininogen-1 (Other) / neurodegeneration (Other)},
      cin          = {AG Wüllner ; AG Wüllner 2},
      ddc          = {610},
      cid          = {I:(DE-2719)1011302},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33179332},
      doi          = {10.1002/mds.28192},
      url          = {https://pub.dzne.de/record/154382},
}