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000154587 1001_ $$0P:(DE-2719)2810906$$aXie, Kan$$b0$$eFirst author$$udzne
000154587 245__ $$aSignaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases.
000154587 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000154587 520__ $$aSeveral laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.
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000154587 650_7 $$2Other$$aAging
000154587 650_7 $$2Other$$aBrain
000154587 650_7 $$2Other$$aDietary energy restriction
000154587 650_7 $$2Other$$aMetabolism
000154587 650_7 $$2Other$$aNeurodegeneration
000154587 650_2 $$2MeSH$$aAnimals
000154587 650_2 $$2MeSH$$aBrain: physiology
000154587 650_2 $$2MeSH$$aCaloric Restriction: methods
000154587 650_2 $$2MeSH$$aCognitive Aging: physiology
000154587 650_2 $$2MeSH$$aHumans
000154587 650_2 $$2MeSH$$aLongevity: physiology
000154587 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000154587 650_2 $$2MeSH$$aNeurodegenerative Diseases: prevention & control
000154587 650_2 $$2MeSH$$aProteostasis
000154587 650_2 $$2MeSH$$aSignal Transduction
000154587 7001_ $$0P:(DE-HGF)0$$aKapetanou, Marianna$$b1
000154587 7001_ $$0P:(DE-HGF)0$$aSidiropoulou, Kyriaki$$b2
000154587 7001_ $$0P:(DE-2719)2158358$$aBano, Daniele$$b3$$udzne
000154587 7001_ $$0P:(DE-HGF)0$$aGonos, Efstathios S$$b4
000154587 7001_ $$0P:(DE-HGF)0$$aDjordjevic, Aleksandra Mladenovic$$b5
000154587 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b6$$eLast author$$udzne
000154587 773__ $$0PERI:(DE-600)1502520-2$$a10.1016/j.mad.2020.111364$$gVol. 192, p. 111364 -$$p111364$$tMechanisms of ageing and development$$v192$$x0047-6374$$y2020
000154587 8564_ $$uhttps://www.sciencedirect.com/science/article/abs/pii/S0047637420301603?via%3Dihub
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