Journal Article

DZNE-2021-00265

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases.

Xie, K. (First author)DZNE* ; Kapetanou, M. ; Sidiropoulou, K. ; Bano, D.DZNE* ; Gonos, E. S. ; Djordjevic, A. M. ; Ehninger, D. (Last author)DZNE*

2020
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.mad.2020.111364

Abstract: Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.

Keyword(s): Animals (MeSH) ; Brain: physiology (MeSH) ; Caloric Restriction: methods (MeSH) ; Cognitive Aging: physiology (MeSH) ; Humans (MeSH) ; Longevity: physiology (MeSH) ; Neurodegenerative Diseases: metabolism (MeSH) ; Neurodegenerative Diseases: prevention & control (MeSH) ; Proteostasis (MeSH) ; Signal Transduction (MeSH) ; Aging ; Brain ; Dietary energy restriction ; Metabolism ; Neurodegeneration

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Contributing Institute(s):

1. Translational Biogerontology (AG Ehninger)
2. Aging and Neurodegeneration (AG Bano)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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