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@ARTICLE{Xie:154587,
      author       = {Xie, Kan and Kapetanou, Marianna and Sidiropoulou, Kyriaki
                      and Bano, Daniele and Gonos, Efstathios S and Djordjevic,
                      Aleksandra Mladenovic and Ehninger, Dan},
      title        = {{S}ignaling pathways of dietary energy restriction and
                      metabolism on brain physiology and in age-related
                      neurodegenerative diseases.},
      journal      = {Mechanisms of ageing and development},
      volume       = {192},
      issn         = {0047-6374},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2021-00265},
      pages        = {111364},
      year         = {2020},
      abstract     = {Several laboratory animal models have shown that dietary
                      energy restriction (ER) can promote longevity and improve
                      various health aspects in old age. However, whether the
                      entire spectrum of ER-induced short- and long-term
                      physiological and metabolic adaptions is translatable to
                      humans remains to be determined. In this review article, we
                      present recent evidence towards the elucidation of the
                      impact of ER on brain physiology and in age-related
                      neurodegenerative diseases. We also discuss modulatory
                      influences of ER on metabolism and overall on human health,
                      limitations of current experimental designs as well as
                      future perspectives for ER trials in humans. Finally, we
                      summarize signaling pathways and processes known to be
                      affected by both aging and ER with a special emphasis on the
                      link between ER and cellular proteostasis.},
      keywords     = {Animals / Brain: physiology / Caloric Restriction: methods
                      / Cognitive Aging: physiology / Humans / Longevity:
                      physiology / Neurodegenerative Diseases: metabolism /
                      Neurodegenerative Diseases: prevention $\&$ control /
                      Proteostasis / Signal Transduction / Aging (Other) / Brain
                      (Other) / Dietary energy restriction (Other) / Metabolism
                      (Other) / Neurodegeneration (Other)},
      cin          = {AG Ehninger / AG Bano},
      ddc          = {610},
      cid          = {I:(DE-2719)1013005 / I:(DE-2719)1013003},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32991920},
      doi          = {10.1016/j.mad.2020.111364},
      url          = {https://pub.dzne.de/record/154587},
}