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001     154587
005     20240219124834.0
024 7 _ |a 10.1016/j.mad.2020.111364
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024 7 _ |a 0047-6374
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037 _ _ |a DZNE-2021-00265
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Xie, Kan
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245 _ _ |a Signaling pathways of dietary energy restriction and metabolism on brain physiology and in age-related neurodegenerative diseases.
260 _ _ |a Amsterdam [u.a.]
|c 2020
|b Elsevier Science
336 7 _ |a article
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520 _ _ |a Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this review article, we present recent evidence towards the elucidation of the impact of ER on brain physiology and in age-related neurodegenerative diseases. We also discuss modulatory influences of ER on metabolism and overall on human health, limitations of current experimental designs as well as future perspectives for ER trials in humans. Finally, we summarize signaling pathways and processes known to be affected by both aging and ER with a special emphasis on the link between ER and cellular proteostasis.
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650 _ 7 |a Aging
|2 Other
650 _ 7 |a Brain
|2 Other
650 _ 7 |a Dietary energy restriction
|2 Other
650 _ 7 |a Metabolism
|2 Other
650 _ 7 |a Neurodegeneration
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brain: physiology
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650 _ 2 |a Caloric Restriction: methods
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650 _ 2 |a Cognitive Aging: physiology
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Longevity: physiology
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: metabolism
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: prevention & control
|2 MeSH
650 _ 2 |a Proteostasis
|2 MeSH
650 _ 2 |a Signal Transduction
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700 1 _ |a Kapetanou, Marianna
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700 1 _ |a Sidiropoulou, Kyriaki
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700 1 _ |a Bano, Daniele
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700 1 _ |a Gonos, Efstathios S
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700 1 _ |a Djordjevic, Aleksandra Mladenovic
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700 1 _ |a Ehninger, Dan
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773 _ _ |a 10.1016/j.mad.2020.111364
|g Vol. 192, p. 111364 -
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|t Mechanisms of ageing and development
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856 4 _ |u https://www.sciencedirect.com/science/article/abs/pii/S0047637420301603?via%3Dihub
856 4 _ |u https://pub.dzne.de/record/154587/files/DZNE-2021-00265_Restricted.pdf
856 4 _ |u https://pub.dzne.de/record/154587/files/DZNE-2021-00265_Restricted.pdf?subformat=pdfa
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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