Journal Article (Erratum/Correction)

DZNE-2021-00292

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine.

Rajewsky, N. ; Almouzni, G. ; Gorski, S. A. ; Aerts, S. ; Amit, I. ; Bertero, M. G. ; Bock, C. ; Bredenoord, A. L. ; Cavalli, G. ; Chiocca, S. ; Clevers, H. ; De Strooper, B. ; Eggert, A. ; Ellenberg, J. ; Fernández, X. M. ; Figlerowicz, M. ; Gasser, S. M. ; Hubner, N. ; Kjems, J. ; Knoblich, J. A. ; Krabbe, G. ; Lichter, P. ; Linnarsson, S. ; Marine, J.-C. ; Marioni, J. C. ; Marti-Renom, M. A. ; Netea, M. G. ; Nickel, D. ; Nollmann, M. ; Novak, H. R. ; Parkinson, H. ; Piccolo, S. ; Pinheiro, I. ; Pombo, A. ; Popp, C. ; Reik, W. ; Roman-Roman, S. ; Rosenstiel, P. ; Schultze, J. L.DZNE* ; Stegle, O. ; Tanay, A. ; Testa, G. ; Thanos, D. ; Theis, F. J. ; Torres-Padilla, M.-E. ; Valencia, A. ; Vallot, C. ; van Oudenaarden, A. ; Vidal, M. ; Voet, T. ; Groups, L. C. W. (Collaboration Author) ; Alberi, L. ; Alexander, S. ; Alexandrov, T. ; Arenas, E. ; Bagni, C. ; Balderas, R. ; Bandelli, A. ; Becher, B. ; Becker, M.DZNE* ; Beerenwinkel, N. ; Benkirane, M. ; Beyer, M.DZNE* ; Bickmore, W. A. ; Biessen, E. E. A. L. ; Blomberg, N. ; Blumcke, I. ; Bodenmiller, B. ; Borroni, B. ; Boumpas, D. T. ; Bourgeron, T. ; Bowers, S. ; Braeken, D. ; Brooksbank, C. ; Brose, N. ; Bruining, H. ; Bury, J. ; Caporale, N. ; Cattoretti, G. ; Chabane, N. ; Chneiweiss, H. ; Cook, S. A. ; Curatolo, P. ; de Jonge, M. I. ; Deplancke, B. ; De Strooper, B. ; de Witte, P. ; Dimmeler, S. ; Draganski, B. ; Drews, A.DZNE* ; Dumbrava, C. ; Engelhardt, S. ; Gasser, T.DZNE* ; Giamarellos-Bourboulis, E. J. ; Graff, C. ; Grün, D. ; Gut, I. G. ; Hansson, O. ; Henshall, D. C. ; Herland, A. ; Heutink, P.DZNE* ; Heymans, S. R. B. ; Heyn, H. ; Huch, M. ; Huitinga, I. ; Jackowiak, P. ; Jongsma, K. R. ; Journot, L. ; Junker, J. P. ; Katz, S. ; Kehren, J. ; Kempa, S. ; Kirchhof, P. ; Klein, C. ; Koralewska, N. ; Korbel, J. O. ; Kühnemund, M. ; Lamond, A. I. ; Lauwers, E. ; Le Ber, I. ; Leinonen, V. ; López-Tobón, A. ; Lundberg, E. ; Lunkes, A. ; Maatz, H. ; Mann, M. ; Marelli, L. ; Matser, V. ; Matthews, P. M. ; Mechta-Grigoriou, F. ; Menon, R. ; Nielsen, A. F. ; Pagani, M. ; Pasterkamp, R. J. ; Pitkänen, A. ; Popescu, V. ; Pottier, C. ; Puisieux, A. ; Rademakers, R. ; Reiling, D. ; Reiner, O. ; Remondini, D. ; Ritchie, C. ; Rohrer, J. D. ; Saliba, A.-E. ; Sanchez-Valle, R. ; Santosuosso, A. ; Sauter, A. ; Scheltema, R. A. ; Scheltens, P. ; Schiller, H. B. ; Schneider, A.DZNE* ; Seibler, P. ; Sheehan-Rooney, K. ; Shields, D. J. ; Sleegers, K. ; Smit, A. B. ; Smith, K. G. C. ; Smolders, I. ; Synofzik, M.DZNE* ; Tam, W. L. ; Teichmann, S. A. ; Thom, M. ; Turco, M. Y. ; van Beusekom, H. M. M. ; Vandenberghe, R. ; Van den Hoecke, S. ; van de Poel, I. ; van der Ven, A. ; van der Zee, J. ; van Lunzen, J. ; van Minnebruggen, G. ; van Oudenaarden, A. ; Van Paesschen, W. ; van Swieten, J. C. ; van Vught, R. ; Verhage, M. ; Verstreken, P. ; Villa, C. E. ; Vogel, J. ; von Kalle, C. ; Walter, J. ; Weckhuysen, S. ; Weichert, W. ; Wood, L. ; Ziegler, A.-G. ; Zipp, F.

2021
Nature Publ. Group London [u.a.]

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Please use a persistent id in citations: doi:10.1038/s41586-021-03287-8

Abstract: Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

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Contributing Institute(s):

1. Clinical Single Cell Omics (CSCO) / Systems Medicine (AG Schultze)
2. Platform for Single Cell Genomics and Epigenomics (Schultze - PRECISE)
3. Immunogenomics and Neurodegeneration (AG Beyer)
4. Parkinson Genetics (AG Gasser)
5. Translational Dementia Research (Bonn) (AG Schneider)
6. Genome Biology of Neurodegenerative Diseases (AG Heutink)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Experiment(s):

1. Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Chemical Reactions ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 60 ; Index Chemicus ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Rajewsky, N. (Corresponding author) ; Almouzni, G. ; Gorski, S. A. ; et al
LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature <London> 587(7834), 377 - 386 (2020) [10.1038/s41586-020-2715-9]2020   Fulltext Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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