Journal Article (Review Article)

DZNE-2021-00296

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Reactive astrocyte nomenclature, definitions, and future directions.

Escartin, C. (Corresponding author) ; Galea, E. (Corresponding author) ; Lakatos, A. ; O'Callaghan, J. P. ; Petzold, G. C. J. P.DZNE* ; Serrano-Pozo, A. ; Steinhäuser, C. ; Volterra, A. ; Carmignoto, G. ; Agarwal, A. ; Allen, N. J. ; Araque, A. ; Barbeito, L. ; Barzilai, A. ; Bergles, D. E. ; Bonvento, G. ; Butt, A. M. ; Chen, W.-T. ; Cohen-Salmon, M. ; Cunningham, C. ; Deneen, B. ; De Strooper, B. ; Díaz-Castro, B. ; Farina, C. ; Freeman, M. ; Gallo, V. ; Goldman, J. E. ; Goldman, S. A. ; Götz, M. ; Gutiérrez, A. ; Haydon, P. G. ; Heiland, D. H. ; Hol, E. M. ; Holt, M. G. ; Iino, M. ; Kastanenka, K. V. ; Kettenmann, H. ; Khakh, B. S. ; Koizumi, S. ; Liddelow, S. A. ; MacVicar, B. A. ; Magistretti, P. ; Messing, A. ; Mishra, A. ; Molofsky, A. V. ; Murai, K. K. ; Norris, C. M. ; Okada, S. ; Oliet, S. H. R. ; Oliveira, J. F. ; Panatier, A. ; Parpura, V. ; Pekna, M. ; Pekny, M. ; Pellerin, L. ; Perea, G. ; Pérez-Nievas, B. G. ; Pfrieger, F. W. ; Poskanzer, K. E. ; Quintana, F. J. ; Ransohoff, R. M. ; Riquelme-Perez, M. ; Robel, S. ; Rose, C. R. ; Rothstein, J. D. ; Rouach, N. ; Rowitch, D. H. ; Semyanov, A. ; Sirko, S. ; Sontheimer, H. ; Swanson, R. A. ; Vitorica, J. ; Wanner, I.-B. ; Wood, L. B. ; Wu, J. ; Zheng, B. ; Zimmer, E. R. ; Zorec, R. ; Sofroniew, M. V. ; Verkhratsky, A. (Corresponding author)

2021
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-020-00783-4

Abstract: Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

Keyword(s): Aging: pathology (MeSH) ; Animals (MeSH) ; Astrocytes: pathology (MeSH) ; Brain: pathology (MeSH) ; Brain Diseases: pathology (MeSH) ; Brain Injuries: pathology (MeSH) ; Humans (MeSH) ; Spinal Cord: pathology (MeSH) ; Spinal Cord Injuries: pathology (MeSH)

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Contributing Institute(s):

1. Neurovascular Diseases (AG Petzold)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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