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000154791 037__ $$aDZNE-2021-00371
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000154791 1001_ $$aMalpetti, Maura$$b0
000154791 245__ $$aApathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.
000154791 260__ $$aHoboken, NJ$$bWiley$$c2021
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000154791 520__ $$aApathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.Presymptomatic carriers of MAPT, GRN or C9orf72 mutations (N = 304), and relatives without mutations (N = 296) underwent clinical assessments and MRI at baseline, and annually for 2 years. Longitudinal changes in apathy, cognition, gray matter volumes, and their relationships were analyzed with latent growth curve modeling.Apathy severity increased over time in presymptomatic carriers, but not in non-carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but not vice versa. Apathy progression was associated with baseline low gray matter volume in frontal and cingulate regions.Apathy is an early marker of FTD-related changes and predicts a subsequent subclinical deterioration of cognition before dementia onset. Apathy may be a modifiable factor in those at risk of FTD.
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000154791 650_7 $$2Other$$aMRI
000154791 650_7 $$2Other$$aapathy
000154791 650_7 $$2Other$$acognitive decline
000154791 650_7 $$2Other$$agenetic frontotemporal dementia
000154791 650_7 $$2Other$$alongitudinal design
000154791 650_7 $$2Other$$apresymptomatic carriers
000154791 650_2 $$2MeSH$$aApathy
000154791 650_2 $$2MeSH$$aAtrophy: pathology
000154791 650_2 $$2MeSH$$aBrain: pathology
000154791 650_2 $$2MeSH$$aCognitive Dysfunction: pathology
000154791 650_2 $$2MeSH$$aFemale
000154791 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000154791 650_2 $$2MeSH$$aGray Matter: pathology
000154791 650_2 $$2MeSH$$aHumans
000154791 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000154791 650_2 $$2MeSH$$aMale
000154791 650_2 $$2MeSH$$aMiddle Aged
000154791 650_2 $$2MeSH$$aMutation: genetics
000154791 650_2 $$2MeSH$$aProdromal Symptoms
000154791 7001_ $$aJones, P Simon$$b1
000154791 7001_ $$aTsvetanov, Kamen A$$b2
000154791 7001_ $$aRittman, Timothy$$b3
000154791 7001_ $$avan Swieten, John C$$b4
000154791 7001_ $$aBorroni, Barbara$$b5
000154791 7001_ $$aSanchez-Valle, Raquel$$b6
000154791 7001_ $$aMoreno, Fermin$$b7
000154791 7001_ $$aLaforce, Robert$$b8
000154791 7001_ $$aGraff, Caroline$$b9
000154791 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b10
000154791 7001_ $$aGalimberti, Daniela$$b11
000154791 7001_ $$aMasellis, Mario$$b12
000154791 7001_ $$aTartaglia, Maria Carmela$$b13
000154791 7001_ $$aFinger, Elizabeth$$b14
000154791 7001_ $$aVandenberghe, Rik$$b15
000154791 7001_ $$ade Mendonça, Alexandre$$b16
000154791 7001_ $$aTagliavini, Fabrizio$$b17
000154791 7001_ $$aSantana, Isabel$$b18
000154791 7001_ $$aDucharme, Simon$$b19
000154791 7001_ $$aButler, Chris R$$b20
000154791 7001_ $$aGerhard, Alexander$$b21
000154791 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b22
000154791 7001_ $$0P:(DE-HGF)0$$aDanek, Adrian$$b23
000154791 7001_ $$aOtto, Markus$$b24
000154791 7001_ $$aFrisoni, Giovanni B$$b25
000154791 7001_ $$aGhidoni, Roberta$$b26
000154791 7001_ $$aSorbi, Sandro$$b27
000154791 7001_ $$aHeller, Carolin$$b28
000154791 7001_ $$aTodd, Emily G$$b29
000154791 7001_ $$aBocchetta, Martina$$b30
000154791 7001_ $$aCash, David M$$b31
000154791 7001_ $$aConvery, Rhian S$$b32
000154791 7001_ $$aPeakman, Georgia$$b33
000154791 7001_ $$aMoore, Katrina M$$b34
000154791 7001_ $$aRohrer, Jonathan D$$b35
000154791 7001_ $$aKievit, Rogier A$$b36
000154791 7001_ $$0P:(DE-HGF)0$$aRowe, James B$$b37$$eCorresponding author
000154791 7001_ $$aGenfi, Genetic Ftd Initiative$$b38
000154791 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.12252$$gVol. 17, no. 6, p. 969 - 983$$n6$$p969 - 983$$tAlzheimer's and dementia$$v17$$x1552-5279$$y2021
000154791 8564_ $$uhttps://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12252
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